Search Results
Overview
| Uniprot ID | A0A286XBR2 |
|---|---|
| Protein Name | Phosphatidylethanolamine-binding protein 1 |
| Gene Name | Pebp1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | GDHRGKFKVASFRKK |
| 47 | VLTPTQVKNRPTSIS |
Function
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation
Protein Sequence
10
MPADVSKWTG
20
PLSLQEVDEQ
30
PKHPLRVSYG
40
GVEVDELGKV
50
LTPTQVKNRP
60
TSISWDGLDS
70
GKLYTLVMTD
80
PDAPSRQSPK
90
FREWHHFLVV
100
NMKGNDISSG
110
TVLSDYVGSG
120
PPSGTGLHRY
130
VWLVYEQDKP
140
LKCDEPILSN
150
RSGDHRGKFK
160
VASFRKKYHL
170
GPPVAGTCYQ
180
AEWDDYVPKL
YEQLSGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.