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Overview

Uniprot ID	A0A286XCZ9
Protein Name	Chromodomain Y-like protein
Gene Name	Cdyl
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
95	PKALVISKDPESKNS

Function

Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain

Protein Sequence

10 VERIVDKRKN 20 KKGKTEYLVR 30 WKGYDSEDDT 40 WEPEQHLVNC 50 EEYIHDFNRR 60 HTEKQKEGAP 70 ARTTRTSPNN 80 ARKQISRSTN 90 STFSKASPKA 100 LVISKDPESK 110 NSPLLAASQK 120 FRKNTASSLS 130 SRKNMDLAKS 140 GIKILVPKSP 150 IKSRTAVDGF 160 PSESPEKLDP 170 IEQGPEDTVA 180 PEVTAEKPVG 190 ALLGPGAERA 200 RMGSRPRIHP 210 LVPQVPGPVT 220 AAMATSLAVN 230 GKGTSPFMDA 240 LTANGTTNIQ 250 TSVTGVAAGK 260 RKFIDDRRDQ 270 PFDKRLRFSV 280 RQTESAYRYR 290 DIVVRKQDGF 300 THILLSTKSS 310 ENNSLNPEVM 320 KEVQSALNTA 330 AADDSKLVLL 340 SAVGSVFCCG 350 LDFIYFIRRL 360 TDDRKRESTK 370 MAEAIRNFVN 380 TFIQFKKPII 390 VAVNGPAIGL 400 GASILPLCDV 410 VWANEKAWFQ 420 TPYTTFGQSP 430 DGCSTVMFPR 440 IMGGASANEM 450 LLSGRKLTAQ 460 EACGKGLVSQ 470 VFWPGTFTQE 480 VMVRIKELAS 490 CNPVVLEESK 500 ALVRCNMKLE 510 LEQANERECE 520 VLKKIWGSAQ 530 GMDSMLKYLQ RKIDEF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0016829	lyase activity
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0007283	spermatogenesis

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.