Search Results
Overview
| Uniprot ID | A0A286XDF1 |
|---|---|
| Protein Name | Transcription elongation factor |
| Gene Name | TCEA1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | MDKMVQKKNAAGALD |
| 55 | MSVNAIRKQSTDEEV |
| 84 | LDGPSTDKDTEEKKK |
Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
Protein Sequence
10
MDDEVVRIAK
20
KMDKMVQKKN
30
AAGALDLLKE
40
LKNIPMTLEL
50
LQSTRIGMSV
60
NAIRKQSTDE
70
EVTSLAKSLI
80
KSWKKLLDGP
90
STDKDTEEKK
100
KEPLITSQNS
110
PEAREESSSS
120
GNVSSRKDET
130
NARDTYVSSF
140
PRAPSTSDSV
150
RLKCREMLAA
160
ALRTGDDYIA
170
IGADEEELGS
180
QIEEAIYQEI
190
RNTDMKYKNR
200
VRSRISNLKD
210
AKNPNLRKNV
220
LCGNIPPDLF
230
ARMTAEEMAS
240
DELKEMRKNL
250
TKEAIREHQM
260
AKTGGTQTDL
270
FTCGKCKKKN
280
CTYTQVQTRS
290
ADEPMTTFVV
300
CNECGNRWKF
C
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.