Search Results

Overview

Uniprot IDA0A286XE49
Protein NameProtein capicua homolog
Gene NameCIC
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
2257 VRPPPLKKTFDSVDN
478 PLTAAQQKYKKGDVV

Function

Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development

Protein Sequence

10 MKPMKKACPG 20 LSGPGSGSKS 30 PPATRAKALR 40 RRGAGDGDKP 50 EEEDDEVQPQ 60 QQPGPEEAEE 70 GEEETEQGLG 80 AERPLPELHP 90 TDLAPGPAED 100 SKGDGEAGRW 110 EPSLSRKTAT 120 FKSRAPKKKY 130 VEEHGAGSGA 140 VTGAPEEQEQ 150 TPEEASTLGV 160 PPQPPTSTRS 170 SSTDTASEHS 180 ADLEDEPAEA 190 CGPGPWPPSG 200 TSGGYDLRQL 210 RSQRVLARRG 220 DGLFLPAVVR 230 QVRRSQDLGV 240 QFPGDRSLTF 250 YEGVPGGGID 260 VVLDATPPPG 270 ALVVGTAVCT 280 CVEPGIAAYR 290 EGVVVEVATK 300 PAAYKVRLSP 310 GPSSQLGPPS 320 TLPQPQQTLH 330 REPEEAVWVA 340 RSSLRLLRPP 350 WEPEGLLRKP 360 PIVPEEEQAE 370 PGTVLPPCPA 380 ALDPKQPEDA 390 EVSKISFGGN 400 LGAHCEEGEE 410 KHPSALSTPA 420 LLPLPPPQLL 430 SPPPKSPAFA 440 GPGRPGEQPS 450 PCQEGSQGGS 460 RSSSVASLEK 470 GTAPAARART 480 PLTAAQQKYK 490 KGDVVCTPNG 500 IRKKFNGKQW 510 RRLCSRDGCM 520 KESQRRGYCS 530 RHLSMRTKEM 540 EGLADSGPGG 550 AGRPAGVAAR 560 EGSTEFDWGD 570 ETSRDSEASS 580 VAARGDSRPR 590 LVAPADLSRF 600 EFDECEAAVM 610 LVSLGSSRSG 620 TPSFSPVSTQ 630 SPFSPAPSPS 640 PSPLFGFRPA 650 NFSPINASPV 660 IQRTAVRSRH 670 LSASTPKAGV 680 LTPPDIGPHP 690 PPPAPRERHS 700 SGILPTFQTN 710 LTFTVPISPG 720 RRKTELLPHP 730 GALGAPGTGG 740 GGAAPDFPKS 750 DSLDSGVDSV 760 SHTPTPSTPA 770 GFRAVSPAVP 780 FSRSRQPSPL 790 LLLPPPAGLT 800 SDPGPSVRRV 810 PAVQRDSPVI 820 VRNPDVPLPS 830 KFPGELGTAG 840 EVRAGGPGRG 850 CRETPVPPGV 860 ASGKPGLPPP 870 LPAPVPITVP 880 PAAPTAVAQP 890 MPTFGLASSP 900 FQPVAFHPSP 910 AALLPVLVPS 920 TYTSHPAPKK 930 EVIMGRPGTV 940 WTNVEPRSVA 950 VFPWHSLVPF 960 LAPSQPDPSV 970 QPNEAQQPAS 980 HPVASNQSKE 990 PAESAAVAHE 1000 QPQGGTGSAD 1010 PGRPPGATCP 1020 ESPGPGPPHT 1030 LGVVEPGKGP 1040 PPTTEEEAPG 1050 PPGEPRLDSE 1060 TESDHDDAFL 1070 SIMSPEIQLP 1080 LPPGKRRTQS 1090 LSALPKERDS 1100 SSEKDGRSPN 1110 KREKDHIRRP 1120 MNAFMIFSKR 1130 HRALVHQRHP 1140 NQDNRTVSKI 1150 LGEWWYALGP 1160 KEKQKYHDLA 1170 FQVKEAHFKA 1180 HPDWKWCNKD 1190 RKKSSSEAKP 1200 TSLGLAGGHK 1210 ETRERSMSET 1220 GTAAAPGVSS 1230 ELLSVAAQTL 1240 LSSDTKAPGS 1250 GSCGAERLHA 1260 VGGPGSARPR 1270 AFSHSGVHSL 1280 DGGEVDSQAL 1290 QELTQMVSGP 1300 TSYSGPKPST 1310 QYGTSGPFAA 1320 PSEGGTLAAS 1330 GRPPLLPTRA 1340 SRSQRAASED 1350 MTSDEERMVI 1360 CEEEGDDDVI 1370 ADDGFGATDI 1380 DLKCKERVTD 1390 SESGDSSGED 1400 PEGNKGFGRK 1410 VFSPVIRSSF 1420 THCRPTLDPE 1430 PPGPPDPPAA 1440 AAFGKGYGPT 1450 PSSSSSSSSS 1460 LAASTSVATS 1470 FSLGSGTFKA 1480 QESGQGSTAV 1490 PLRPPLSGAG 1500 GPATPSKVTR 1510 FLPTDPANFR 1520 RKRPESVGGL 1530 EPPGPSVISA 1540 PPSGGGNILQ 1550 TLVLPSNKEE 1560 REGSGARVPS 1570 TPAPSLAYGA 1580 PAAPLSRPAA 1590 TMVTSVVRPV 1600 SSTPVPIASK 1610 PFPTSGRAEA 1620 SPNDTAGART 1630 EMGTGSRVPG 1640 GSPLGVSLVY 1650 SDKKSAATSP 1660 APHLVAGPLL 1670 GTVGKAPATV 1680 TNLLVGTPGY 1690 GAPAPPAVQF 1700 ITQGAPSSGT 1710 TAGSGAGSGS 1720 GPNGPVPLGI 1730 LQSGALGKAG 1740 GITQVQYILP 1750 TLPQQLQVAP 1760 APAAAPGTKS 1770 AAPSGPVPTT 1780 SIRFTLPPGT 1790 STNGKVLAAT 1800 APTPGIPILQ 1810 SVPSAPPPKA 1820 QSVSPVQAPP 1830 PGGSAQLLPG 1840 KVLVPLATPS 1850 MSVRSGGAGQ 1860 SLPLVSPPFS 1870 VPVQNGAQPP 1880 SKIIQLTPVP 1890 VSTPSGLVPP 1900 LSPAPLPGTT 1910 SQPQKVLLPS 1920 STRITYVQSA 1930 GGHTLPLGTS 1940 PVSSQAGAVT 1950 SYGPTSSVAL 1960 GFTSLGPSGP 1970 AFVQPLLSGQ 1980 APLLAPGQVG 1990 VSPVPSPQLP 2000 PACTAPGGPV 2010 ITAFYPGSPA 2020 PSSSAPVAQP 2030 SQAPPSLVYT 2040 VATSTTPPAA 2050 TTILPKGPPV 2060 PATATPAPTS 2070 PFPSATGGSM 2080 TYSLVAPKAQ 2090 RPSPKAPQKV 2100 KAAIASIPVG 2110 SFEAGATGRP 2120 GPVSRQPLES 2130 GPAREPATPD 2140 TELEGQPTPP 2150 APPPPPETWP 2160 PTARSSPPPP 2170 LPAEERTGTK 2180 VPDAMASKFS 2190 SSSSDWRVPG 2200 MSLESRGEPP 2210 TPPSPAPAPA 2220 TAPGGSSSSS 2230 SSSSEGSSGR 2240 AAGDTPERKE 2250 AASTGKKVKV 2260 RPPPLKKTFD 2270 SVDNRVLSEV 2280 DFEERFAELP 2290 EFRPEEVLPS 2300 PTLQSLATSP 2310 RAILGSYRKK 2320 RKNSTDLDSA 2330 PEDPTSPKRK 2340 MRRRSSCSSE 2350 PNTPKSAKCE 2360 GDIFTFDRTG 2370 TEAEDVLGEL 2380 EYEKVPYSSL 2390 RRTLDQRRAL 2400 VMQLFQDHGF 2410 FPSAQATAAF 2420 QARYADIFPS 2430 KVCLQLKIRE 2440 VRQKIMQAAT 2450 PTEQPPGAEP 2460 PLPGPPPAGT 2470 AATPAPTPSP 2480 AGGPDPTLPS 2490 SDSGTAQAAP 2500 PLPPPPEPGS 2510 GQPGWEGAPH 2520 PSPPSGPSTA ATSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0007420 brain development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007612 learning
Biological Process GO:0007613 memory
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0035176 social behavior

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.