Overview
| Uniprot ID | A0A286XEV3 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | CAPZB |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 252 |
SVQTFADKSKQEALK |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MSDQQLDCAL
20
DLMRRLPPQQ
30
IEKNLSDLID
40
LVPSLCEDLL
50
SSVDQPLKIA
60
RDKMVGKDYL
70
LCDYNRDGDS
80
YRSPWSNKYD
90
PPLEDGAMPS
100
ARLRKLEVEA
110
NNAFDQYRDL
120
YFEGGVSSVY
130
LWDLDHGFAG
140
VILIKKAGDG
150
SKKIKGCWDS
160
IHVVEVQEKS
170
SGRTAHYKLT
180
STVMLWLQTN
190
KSGSGTMNLG
200
GSLTRQMEKD
210
ETVSDCSPHI
220
ANIGRLVEDM
230
ENKIRSTLNE
240
IYFGKTKDIV
250
NGLRSVQTFA
260
DKSKQEALKN
270
DLVEALKRKQ
QC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
| Biological Process |
GO:0000902 |
cell morphogenesis |
| Biological Process |
GO:0051490 |
negative regulation of filopodium assembly |
| Biological Process |
GO:0010591 |
regulation of lamellipodium assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.