Search Results
Overview
| Uniprot ID | A0A286XFC0 |
|---|---|
| Protein Name | Dihydropyrimidinase-related protein 1 |
| Gene Name | CRMP1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 601 | QRVKIRNKVAGLHGV |
| 634 | ATPAPSAKSSPSKHQ |
| 639 | SAKSSPSKHQPPPIR |
Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis
Protein Sequence
10
MADRRRAWNT
20
EDDLPVYLAR
30
PGSAAQTPRQ
40
KYGGMFAAVE
50
GAYENKTIDF
60
DAYSVGRRGS
70
ARTPRSAGRL
80
DAVGIPGPGG
90
SEDTASDVSE
100
LSGSAVSSPG
110
ERDERPPALR
120
IRCPAPRDLP
130
LGRDNGQSDR
140
LLIKGGRIIN
150
DDQSFYADVY
160
LEDGLIKQIG
170
ENLIVPGGVK
180
TVEANGRMVI
190
PGGIDVNTYL
200
QKPCQGMTAA
210
DDFFQGTKAA
220
LAGGTTMIID
230
HVVPEPGSSL
240
LTSFEKWHEA
250
ADTKSCCDYS
260
LHVDITSWYD
270
GVREELEVLV
280
QDKGVNSFQV
290
YMAYKDLYQM
300
SDSQLYEAFT
310
FLKGLGAVIL
320
VHAENGDLIA
330
QEQKRILEMG
340
ITGPEGHALS
350
RPEELEAEAV
360
FRAITIAGRI
370
NCPVYITKVM
380
SKSAADIITL
390
ARKKGPLVFG
400
EPIAASLGTD
410
GTHYWSKNWA
420
KAAAFVTSPP
430
LSPDPTTPDY
440
LTSLLACGDL
450
QVTGSGHCPY
460
STAQKAVGKD
470
NFTLIPEGVN
480
GIEERMTVVW
490
DKAVATGKMD
500
ENQFVAVTST
510
NAAKIFNLYP
520
RKGRIAVGSD
530
ADVVIWDPDK
540
VKTITAKSHK
550
SAVEYNIFEG
560
MECHGSPLVV
570
ISQGKIVFED
580
GNISVNKGMG
590
RFIPRKPFPE
600
HLYQRVKIRN
610
KVAGLHGVSR
620
GMYDGPVYEV
630
PATPKYATPA
640
PSAKSSPSKH
650
QPPPIRNLHQ
660
SNFSLSGAQI
670
DDNNPRRTGH
680
RIVAPPGGRS
NITSLG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0031005 | filamin binding |
| Molecular Function | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
| Biological Process | GO:0071526 | semaphorin-plexin signaling pathway |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.