Search Results
Overview
| Uniprot ID | A0A286XFH5 |
|---|---|
| Protein Name | DNA repair nuclease/redox regulator APEX1 |
| Gene Name | APEX1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 24 | PKREPEAKKSKAGPK |
| 32 | KSKAGPKKNEKEEAG |
| 7 | *MPKRGKKGSVAEDG |
Function
Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends
Protein Sequence
10
MPKRGKKGSV
20
AEDGEEPKRE
30
PEAKKSKAGP
40
KKNEKEEAGE
50
GPALYEDPPD
60
KKTSPSGKSA
70
TLKICSWNVD
80
GLRAWIKKKG
90
LDWVKEEAPD
100
ILCLQETKCS
110
ENKLPAELQE
120
LSELSHQYWS
130
APSDKEGYSG
140
VGLLSRQCPI
150
KVSYGIGEEE
160
HDQEGRVIVA
170
EFDSFVLVTA
180
YVPNAGRGLV
190
RLEYRQRWDE
200
AFRKFLKGLA
210
SRKPLVLCGD
220
LNVAHEEIDL
230
RNPKGNKKNA
240
GFTPQERQGF
250
GELLQAVPLA
260
DSFRHLYPNA
270
AYAYTFWTYM
280
MNARSKNVGW
290
RLDYFLLSHS
300
LLPALCDSKI
310
RSKALGSDHC
PITLYLAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0052720 | class II DNA-(apurinic or apyrimidinic site) endonuclease activity |
| Molecular Function | GO:0033892 | deoxyribonuclease (pyrimidine dimer) activity |
| Molecular Function | GO:0140431 | DNA-(abasic site) binding |
| Molecular Function | GO:0008311 | double-stranded DNA 3'-5' DNA exonuclease activity |
| Molecular Function | GO:0003691 | double-stranded telomeric DNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0090580 | phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006308 | DNA catabolic process |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0044029 | positive regulation of gene expression via chromosomal CpG island demethylation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0097698 | telomere maintenance via base-excision repair |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.