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Overview

Uniprot ID	A0A286XGR7
Protein Name	Ran-binding protein 3
Gene Name	RANBP3
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
369	ESAAAYTKATARKCL

Function

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export

Protein Sequence

10 MADLANEEKP 20 AIAPPVFVFQ 30 KDKGQKSSAE 40 QKNLSDSGEE 50 PQGGAEAPHH 60 GTGHPESAGQ 70 RALEPPAPAS 80 MWASTPPPAP 90 EAQPPFLQKL 100 SGRSAGGSSP 110 EAGEDSDRED 120 GNYCPPVKRE 130 RTSSLTQLPT 140 SQAEEKSSGF 150 RLKPPTLIHG 160 QAPSAGLPSQ 170 KPKEQQRSVL 180 RPAVLQAPQP 190 KVLAQTVPSS 200 GTNGVSIPAG 210 CTGAAAASSP 220 ENPARRSPSE 230 AAAEALLLEK 240 KEPRRDECSD 250 ASEEEGTRQA 260 FVFGQNLRDR 270 VKLMNENMDA 280 ADVESTGQPS 290 SETPAATNYF 300 LQYISSSAEN 310 STNSADASSN 320 KFVFGQNMSE 330 RVLSPPKLNE 340 VSSDANRESA 350 AAESGSESSS 360 QEATPEKESL 370 AESAAAYTKA 380 TARKCLLEKV 390 EVVTGEEAES 400 NVLQIQCKLF 410 VFDKTSQSWV 420 ERGRGLLRLN 430 DMASADDGTL 440 QSRLVMRTQG 450 SLRLILNTKL 460 WAQMQIDKAS 470 EKSIRITAMD 480 TEDQGVKVFL 490 ISASSKDTGQ 500 LYAALHHRIL 510 ALRSRVEQEQ 520 EAQAPAPEPG 530 APSNEDDSDD 540 DLLAPSGAPG 550 ASASEEGDGQ APGST

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0006611	protein export from nucleus

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.