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Overview

Uniprot IDA0A286XHX4
Protein NameCentromere protein V
Gene NameCENPV
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
109 AQHTFCKKCGVQSFY
161 MKEHKTIKNMSKE**
87 ASRFKLLKGAESITT

Function

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis

Protein Sequence

10 ELGAQRERWE 20 AFPEAAEAQL 30 RGRAKLLLDT 40 FEYQGLVKHT 50 GGCHCGAVRF 60 EVWASADLHI 70 FDCNCSICKK 80 KQNKHFIVPA 90 SRFKLLKGAE 100 SITTYTFNTH 110 KAQHTFCKKC 120 GVQSFYTPRS 130 NPGGFGIAPH 140 CLDEGTVRSV 150 VTEEFNGSDW 160 EKAMKEHKTI KNMSKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005876 spindle microtubule
Cellular Component GO:0051233 spindle midzone
Molecular Function GO:0016846 carbon-sulfur lyase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0031508 pericentric heterochromatin formation
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0033044 regulation of chromosome organization

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.