Search Results
Overview
| Uniprot ID | A0A286XID4 |
|---|---|
| Protein Name | peptidylprolyl isomerase |
| Gene Name | Fkbp1a |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | PFKFMLGKQEVIRGW |
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Protein Sequence
10
MGVQVETISP
20
GDGRTFPKRG
30
QTCVVHYTGM
40
LEDGKKFDSS
50
RDRNKPFKFM
60
LGKQEVIRGW
70
EEGVAQMSVG
80
QRAKLTISPD
90
YAYGAKGHPG
100
IIPPHATLVF
DVELLKLE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005528 | FK506 binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0060347 | heart trabecula formation |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.