Search Results
Overview
| Uniprot ID | A0A286XJM1 |
|---|---|
| Protein Name | Core histone macro-H2A |
| Gene Name | MACROH2A2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | IHPELLAKKRGTKGK |
| 134 | ILSPPPEKRGRKATS |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes
Protein Sequence
10
MSGRSGKKKM
20
SKLSRSARAG
30
VIFPVGRLMR
40
YLKKGTFKYR
50
ISVGAPVYMA
60
AVIEYLAAEI
70
LELAGNAARD
80
NKKARIAPRH
90
ILLAVANDEE
100
LNQLLKGVTI
110
ASGGVLPRIH
120
PELLAKKRGT
130
KGKSETILSP
140
PPEKRGRKAT
150
SGKKGGKKAK
160
AAKPRASKKS
170
KPKDSDKEGT
180
SNSTSEDGPG
190
DGFTILSSKS
200
LVLGQKLSLT
210
QSDISHIGSM
220
RVEGIVHPTT
230
AEIDLKEDIG
240
KALEKAGGKE
250
FLETVKELRK
260
SQGPLEVAEA
270
AVSQSSGLAA
280
KFVIHCHIPQ
290
WGSDKCEEQL
300
EETIKNCLSA
310
AEDKKLKSVA
320
FPPFPSGRNC
330
FPKQTAAQVT
340
LKAISAHFDD
350
SNTSSLKNVY
360
FLLFDSESIG
370
IYVQEMAKLD
TK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001740 | Barr body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
| Biological Process | GO:0045814 | negative regulation of gene expression, epigenetic |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901837 | negative regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0045618 | positive regulation of keratinocyte differentiation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.