Search Results

Overview

Uniprot IDA0A286XLP8
Protein NameProbable ATP-dependent RNA helicase DDX46
Gene NameDDX46
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1013 NSYQPTNKGRYKVL*
263 KSGPTVTKVVTVVTT
271 VVTVVTTKKAVVDSD
764 KSSGFSGKGFKFDET

Function

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site

Protein Sequence

10 MGRESRHYRK 20 RSASRGRSGS 30 RSRSRSPSDK 40 RSKRGDDRRS 50 RSRDRDRRRE 60 RSRSRDKRRS 70 RSRDRKRLRR 80 SRSRERDRSR 90 ERRRSRSRDR 100 RRSRSRSRGR 110 RSRSSSPGNK 120 SKKAENRSRS 130 KEKTEGGESS 140 KEKKKDKDDK 150 EDEKEKDAGN 160 FDQNKLEEEM 170 RKRKERVEKW 180 REEQRKKAME 190 NIGELKKEIE 200 EMKQGKKWSL 210 EDDDDDEDDP 220 AEAEKEGNEM 230 EGEELDPLDA 240 YMEEVKEEVK 250 KFNMRSVKGG 260 GGNEKKSGPT 270 VTKVVTVVTT 280 KKAVVDSDKK 290 KGELMENDQD 300 AMEYSSEEEE 310 VDLQTALTGY 320 QTKQRKLLEP 330 VDHGKIEYEP 340 FRKNFYVEVP 350 ELAKMSQEEV 360 NVFRLEMEGI 370 TVKGKGCPKP 380 IKSWVQCGIS 390 MKILNSLKKH 400 GYEKPTPIQT 410 QAIPAIMSGR 420 DLIGIAKTGS 430 GKTIAFLLPM 440 FRHIMDQRSL 450 EEGEGPIAVI 460 MTPTRELALQ 470 ITKECKKFSK 480 TLGLRVVCVY 490 GGTGISEQIA 500 ELKRGAEIIV 510 CTPGRMIDML 520 AANSGNFRDY 530 SSYLLTLFSQ 540 VMRIVDNVRP 550 DRQTVMFSAT 560 FPRAMEALAR 570 RILSKPIEVQ 580 VGGRSVVCSD 590 VEQQVIVIEE 600 EKKFLKLLEL 610 LGHYQESGSV 620 IIFVDKQEHA 630 DGLLKDLMRA 640 SYPCMSLHGG 650 IDQYDRDSII 660 NDFKNGTCKL 670 LVATSVAARG 680 LDVKHLILVV 690 NYSCPNHYED 700 YVHRAGRTGR 710 AGNKGYAYTF 720 ITEDQARYAG 730 DIIKALELSG 740 TVVPPDLEKL 750 WSDFKDQQKA 760 EGKIIKKSSG 770 FSGKGFKFDE 780 TEQALANERK 790 KLQKAALGLQ 800 DSDDEDAAVD 810 IDEQIESMFN 820 SKKRVKDMAA 830 PGTSSVPAPT 840 AGNAEKLEIA 850 KRLALRINAQ 860 KNLGIESQDV 870 MQQATNAILR 880 GGTILAPTVS 890 AKTIAEQLAE 900 KINAKLNYVP 910 LEKQEEERQD 920 GGQNESFKRY 930 EEELEINDFP 940 QTARWKVTSK 950 EALQRISEYS 960 EAAITIRGTY 970 FPPGKEPKEG 980 ERKIYLAIES 990 ANELAVQKAK 1000 AEITRLIKEE 1010 LIRLQNSYQP TNKGRYKVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.