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Overview

Uniprot ID	A0A286XM82
Protein Name	ATP-citrate synthase
Gene Name	ACLY
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
488	SPRPLQGKSATLFSR

Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

Protein Sequence

10 MSAKAISEQT 20 GKELLYKYIC 30 TTSAIQNRFR 40 YARVTPDTDW 50 ARLLQDHPWL 60 LSQSLVVKPD 70 QLIKRRGKLG 80 LVGINLSLDG 90 VKSWLKPRLG 100 QEAVVGKARG 110 FLKNFLIEPF 120 VPHSQAEEFY 130 VCIYAAREGD 140 YVLFHHEGGV 150 DVGDVDAKAQ 160 KLLVGVDKKL 170 SSEDVREHLL 180 VHVPADKKEV 190 LASFICGLFN 200 FYEDLYFTYL 210 EINPLVVTKD 220 GVYVLDLAAK 230 VDATADYICK 240 VKWGDIEFPP 250 PFGREAYPEE 260 AYIADLDAKS 270 GASLKLTLLN 280 PKGRIWTMVA 290 GGGASVVYSD 300 TICDLGGVNE 310 LANYGEYSGA 320 PSEQQTYDYA 330 KTILSLMTRE 340 KHPEGKILII 350 GGSIANFTNV 360 AATFKGIVRA 370 IRDYQGPLKE 380 HEVTIFVRRG 390 GPNYQEGLRV 400 MGEVGKTTGI 410 PIHVFGTETH 420 MTAIVGMALG 430 HRPIPNQPPM 440 AAHTANFLLN 450 ASGSTSTPAP 460 SRTASFSESR 470 ADEVAPAKKA 480 KPAVLQDSDP 490 SPRPLQGKSA 500 TLFSRHTKAI 510 VWGMQTRAVQ 520 GMLDFDYVCS 530 RDEPSVAAMV 540 YPFTGDHKQK 550 FYWGHKEILI 560 PVFKNMGDAM 570 KKHPEVDVLI 580 NFASLRSAYD 590 STMETMNHAQ 600 IRTIAIIAEG 610 IPEALTRKLI 620 QTAERKGVTI 630 IGPATVGGIK 640 PGCFKIGNTG 650 GMLDNILASK 660 LYRPGSVAYV 670 SRSGGMSNEL 680 NNIISRTTDG 690 VYEGVAIGGD 700 RYPGSTFMDH 710 VLRYQDTPGV 720 KMIVVLGEIG 730 GTEEYKICSA 740 IQEGRLTKPV 750 VCWCIGTCAT 760 MFSSEVQFGH 770 AGACANQASE 780 TAVAKNQALK 790 EAGVFVPRSF 800 DELGEIIQSV 810 YEDLVTRGVI 820 VPAQEVPPPT 830 VPMDYSWARE 840 LGLIRKPASF 850 MTSICDERGQ 860 ELIYAGMPIT 870 EVFKEEMGIG 880 GVLGLLWFQR 890 RLPKYACQFI 900 EMCLMVTADH 910 GPAVSGAHNT 920 IICARAGKDL 930 VSSLTSGLLT 940 IGDRFGGALD 950 AAAKMFSKAF 960 DSGMIPMEFV 970 NKMKKEGKLI 980 MGIGHRVKSI 990 NNPDMRVQIL 1000 KDFVRQHFPA 1010 LPLLDYALQV 1020 EKITTSKKPN 1030 LILNVDGLIG 1040 VAFVDMLRNC 1050 GSFTREEADE 1060 YIDIGALNGI 1070 FVLGRSMGFI 1080 GHYLDQKRLK 1090 QGLYRHPWDD 1100 ISYVLPEHMS M

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003878	ATP citrate synthase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006085	acetyl-CoA biosynthetic process
Biological Process	GO:0006101	citrate metabolic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0110076	negative regulation of ferroptosis
Biological Process	GO:0006107	oxaloacetate metabolic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.