Overview
| Uniprot ID | A0A286XP64 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein K |
|---|
| Gene Name | LOC100726317 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 155 |
AGGIIGVKGAKIKEL |
| 363 |
LAGSIIGKGGQRIKQ |
| 52 |
NAGAVIGKGGKNIKA |
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation
Protein Sequence
10
METEQPEETF
20
PNTETNGEFG
30
KHPAEDMEEE
40
QAFKRSRNTD
50
EMSKNAGAVI
60
GKGGKNIKAL
70
RTDYNASVSV
80
PDSSGPKRIL
90
SISGDIETIG
100
EILKKIIPTL
110
EECRQLPLPI
120
ATSQLPLESD
130
AVECLNYQHY
140
KGSDFDCELR
150
LLIHQSLAGG
160
IIGVKGAKIK
170
ELLENTQTTI
180
KLFQECLECI
190
KIILDLISES
200
PIKGHYGGFT
210
MMFDDRCGHP
220
VGFPMRGRGG
230
FDRMPPGQGG
240
RPMPPSRRDY
250
DDRSPSRGPP
260
PSLPGRGGRG
270
GSRARNLPLP
280
PPPPPRGGDL
290
MAYDRRGRPG
300
DRYDGMVGFS
310
ADETWDSAID
320
TWSPSEWQMA
330
CEPQGGSDYS
340
YAGGRGSCGD
350
LGGPIITAEV
360
TIPKDLAGSI
370
IGKGGQRIKQ
380
IRHVSGASIK
390
IDEPLEGSED
400
RIITITGTQD
410
QIQNAQYLLQ
420
NSVKQYSGKF
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.