Search Results
Overview
| Uniprot ID | A0A286XP99 |
|---|---|
| Protein Name | Mitochondrial peptide methionine sulfoxide reductase |
| Gene Name | MSRA |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 39 | QEALPGRKEAISVAA |
Function
Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency
Protein Sequence
10
MLSGIARARQ
20
LLRGLLPGSR
30
MGDSASTLVS
40
PQEALPGRKE
50
AISVAAKHHV
60
NGNRTVEPFP
70
EGTQMAVFGM
80
GCFWGAERKF
90
WILKGVYSTQ
100
VGFAGGYTPN
110
PTYKEVCSGK
120
TGHAEVIRVV
130
YQPEHISFEE
140
LLKVFWENHD
150
PTQGMRQGND
160
HGTQYRSAIY
170
PTCAAQMQAA
180
LQSKEDYQKS
190
LSAHGFGPIT
200
TDIREGQTFY
210
YAEDYHQQYL
220
SKIPDGYCGL
230
RGTGISCPLG
IKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.