Search Results
Overview
| Uniprot ID | A0A286XPP2 |
|---|---|
| Protein Name | Neurofilament medium polypeptide |
| Gene Name | Nefm |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 707 | DVATKPGKVSVEKEA |
| 810 | VVTKTIEKITSEGGD |
| 825 | GATKYITKSVTVTQK |
| 852 | VSTKKVEKVTSHAIV |
| 860 | VTSHAIVKEVTQSD* |
Function
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks
Protein Sequence
10
MSYTLDPLGN
20
PSAYRRITET
30
RSSFSRVSGS
40
PSSGFRSQSW
50
SRGSPSTVSS
60
SYKRSALAPR
70
LAYSSAMLSS
80
AESSLDFSQS
90
SSLLNGGSGG
100
DYKLSRSNEK
110
EQLQGLNDRF
120
AGYIEKVHFL
130
EQQNKEIEAE
140
IQALRQKQAS
150
HAQLGDAYDQ
160
EIRELRATLE
170
LVNHEKAQVQ
180
LDSDHLEEDI
190
HRLKERFEEE
200
ARLRDDTEAA
210
IRALRKDIEE
220
SSLVKVELDK
230
KVQSLQDEVA
240
FLRSNHEEEV
250
ADLLAQIQAS
260
HITVERKDYL
270
KTDISTALKE
280
IRSQLECHSD
290
QNMHQAEEWF
300
KCRYAKLTEA
310
AEQNKEAIRS
320
AKEEIAEYRR
330
QLQSKSIELE
340
SVRGTKESLE
350
RQLSDIEERH
360
NHDLSSYQDT
370
IQQLENELRG
380
TKWEMARHLR
390
EYQDLLNVKM
400
ALDIEIAAYR
410
KLLEGEETRF
420
STFAGSITGP
430
IYTHRQPSVT
440
ISSKIQKTKV
450
EAPKLKVQHK
460
FVEEIIEETK
470
VEDEKSEMED
480
ALTAIAEELA
490
VSAKEEKGEE
500
AEEKKEEKEA
510
EEEVVAAKES
520
PVKATAPEIK
530
GEEEEEKEEE
540
GQEEEEEEDE
550
GVKSDQAEEG
560
GSEKEGSSEK
570
DEGEQEEEGE
580
VEVEGEGEEA
590
EAKEEKKSEE
600
LASKEELVAE
610
AKAGKPEKAK
620
SPAPKSPVEE
630
VKPKAEAVAG
640
KGEQKEEEKV
650
EEEKKEVAKE
660
SPKEEKVEKK
670
EEKPKDVPEK
680
KKAESPVKEK
690
AESPVKEKAE
700
SPVKEKAVED
710
VATKPGKVSV
720
EKEAKEEEKP
730
KEKEKKEKPE
740
EEGVREEEGS
750
GQVPKGSRKE
760
DIAVNGEVEG
770
KEEEEQETKE
780
IGSGREEEKG
790
VVTNGLDVSP
800
AEERKGGDRS
810
DVVVTKTIEK
820
ITSEGGDGAT
830
KYITKSVTVT
840
QKVEEHEETF
850
EEKLVSTKKV
860
EKVTSHAIVK
EVTQSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0033693 | neurofilament bundle assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.