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Overview

Uniprot ID	A0A286XQV4
Protein Name	Poly(A) polymerase
Gene Name	PAPOLA
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
607	TSGNAATKIPNPIAG

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's

Protein Sequence

10 MPFPVTTQGS 20 QQTQPPQKHY 30 GITSPISLAA 40 PKETDWVLTQ 50 KLIETLKPFG 60 VFEEEEEPQR 70 RILILGKLNN 80 LVKEWIREIS 90 ESKADIDALC 100 VAPRHVDRSD 110 FFTSFYDKLK 120 LQEEVKDLRA 130 VEEAFVPVIK 140 LCFDGIEIDI 150 LFARLALQTI 160 PEDLDLRDDS 170 LLKNLDIRCI 180 RSLNGCRVTD 190 EILHLVPNID 200 NFRLTLRAIK 210 LWAKRHNIYS 220 NILGFLGGVS 230 WAMLVARTCQ 240 LYPNAIASTL 250 VHKFFLVFSK 260 WEWPNPVLLK 270 QPEECNLNLP 280 VWDPRVNPSD 290 RYHLMPIITP 300 AYPQQNSTYN 310 VSVSTRMVMV 320 EEFKQGLAIT 330 DEILLSKAEW 340 SKLFEAPNFF 350 QKYKHYIVLL 360 ASAPTEKQRL 370 EWVGLVESKI 380 RILVGSLEKN 390 EFITLAHVNP 400 QSFPAPKENP 410 DKEEFRTMWV 420 IGLVFKKTEN 430 SENLSVDLTY 440 DIQSFTDTVY 450 RQAINSKMFE 460 VDMKIAAMHV 470 KRKQLHQLLP 480 NHVLQKKKKH 490 STEGVKLTAL 500 NDSSLDLSMD 510 SDNSMSVPSP 520 TSATKTSPLN 530 SSGSSQGRNS 540 PAPAVTAASV 550 TNIQAPEVSV 560 PQTNSSDSSG 570 GTSSESIPQT 580 ATQPAISPPP 590 KPTVSRVVSS 600 TRLVNPPPRT 610 SGNAATKIPN 620 PIAGVKRTSS 630 PHKEESPKKP 640 KTDEKTSSTD 650 LSDIPALPAN 660 PIPVIKNSIK LRLNR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:1990817	poly(A) RNA polymerase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0031123	RNA 3'-end processing

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.