Overview
| Uniprot ID | A0A286XR81 |
|---|
| Protein Name | Cleavage and polyadenylation specificity factor subunit 5 |
|---|
| Gene Name | NUDT21 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 23 |
GVNQFGNKYIQQTKP |
Function
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs
Protein Sequence
10
MSVVPPNRSQ
20
TGWPRGVNQF
30
GNKYIQQTKP
40
LTLERTINLY
50
PLTNYTFGTK
60
EPLYEKDSSV
70
AARFQRMREE
80
FDKIGMRRTV
90
EGVLIVHEHR
100
LPHVLLLQLG
110
TTFFKLPGGE
120
LNPGEDEVEG
130
LKRLMTEILG
140
RQDGVLQDWV
150
IDDCIGNWWR
160
PNFEPPQYPY
170
IPAHITKPKE
180
HKKLFLVQLQ
190
EKVPKNYKLV
200
AAPLFELYDN
210
APGYGPIISS
220
LPQLLSRFNF
IYN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005847 |
mRNA cleavage and polyadenylation specificity factor complex |
| Cellular Component |
GO:0042382 |
paraspeckles |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042826 |
histone deacetylase binding |
| Molecular Function |
GO:0035925 |
mRNA 3'-UTR AU-rich region binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0180010 |
co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway |
| Biological Process |
GO:0110104 |
mRNA alternative polyadenylation |
| Biological Process |
GO:2000975 |
positive regulation of pro-B cell differentiation |
| Biological Process |
GO:2000738 |
positive regulation of stem cell differentiation |
| Biological Process |
GO:0010608 |
post-transcriptional regulation of gene expression |
| Biological Process |
GO:0051290 |
protein heterotetramerization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.