Search Results
Overview
| Uniprot ID | A0A286XRC7 |
|---|---|
| Protein Name | SOSS complex subunit C |
| Gene Name | INIP |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 53 | LCRPSLNKDFRDHAE |
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs)
Protein Sequence
10
MAANSSGQGF
20
QNKNRVAILA
30
ELDKEKRKLL
40
MQNQSSTNHP
50
GASIALCRPS
60
LNKDFRDHAE
70
QQHIAAQQKA
80
ALQHAHAHSS
90
GYFITQDSAF
100
GNLILPVLPR
LDPE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0035861 | site of double-strand break |
| Cellular Component | GO:0070876 | SOSS complex |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0044818 | mitotic G2/M transition checkpoint |
| Biological Process | GO:0010212 | response to ionizing radiation |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.