Search Results
Overview
| Uniprot ID | A0A286XRP5 |
|---|---|
| Protein Name | Cone-rod homeobox protein |
| Gene Name | CRX |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | QPPGAQAKARPAKRK |
Function
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors
Protein Sequence
10
MMAYMNPGPH
20
YSVNALALSG
30
PSVDLMHQAV
40
PYPSAPRKQR
50
RERTTFTRSQ
60
LEELEALFAK
70
TQYPDVYARE
80
EVALKINLPE
90
SRVQVWFKNR
100
RAKCRQQRQQ
110
QKQQQQQQPP
120
GAQAKARPAK
130
RKAGGSPRPS
140
TDVCPDPLGI
150
SDSYSPPLPG
160
PSGSPTTAVA
170
TVSIWSPASE
180
SPLPEAQRAG
190
LVTSGPSLSS
200
APYAMTYAPA
210
SAFCSSPSAY
220
GSPSSYFSGL
230
DPYLSPMVPQ
240
LGGPALSPLS
250
GPSVGPSLAQ
260
SPTSLSGQSY
270
GAYSPVDSLE
280
FKDPTGTWKF
290
TYNPMDPLDY
300
KDQSAWKFQI
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0043522 | leucine zipper domain binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0007399 | nervous system development |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.