Overview
| Uniprot ID | A0A286XSB8 |
|---|
| Protein Name | U6 snRNA-associated Sm-like protein LSm6 |
|---|
| Gene Name | LSM6 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 5 |
***MSLRKQTPSDFL |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway
Protein Sequence
10
MSLRKQTPSD
20
FLKQIIGRPV
30
VVKLNSGVDY
40
RGVLACLDGY
50
MNIALEQTEE
60
YVNGQLKNKY
70
GDAFIRGNNV
80
LYISTQKRRM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0071005 |
U2-type precatalytic spliceosome |
| Cellular Component |
GO:0120115 |
Lsm2-8 complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0005732 |
sno(s)RNA-containing ribonucleoprotein complex |
| Cellular Component |
GO:0046540 |
U4/U6 x U5 tri-snRNP complex |
| Cellular Component |
GO:0005688 |
U6 snRNP |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0030490 |
maturation of SSU-rRNA |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0008033 |
tRNA processing |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.