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Overview

Uniprot ID	A0A286XT26
Protein Name	Ubiquitin-like protein NEDD8
Gene Name	NEDD8
Organism	Cavia porcellus

Kla Sites from experimental identification

Position	Flanking peptide
48	QRLIYSGKQMNDEKT
54	GKQMNDEKTAADYKI

Function

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M

Protein Sequence

10 MLIKVKTLTG 20 KEIEIDIEPT 30 DKVERIKERV 40 EEKEGIPPQQ 50 QRLIYSGKQM 60 NDEKTAADYK 70 ILGGSVLHLV 80 LALRGGGGLR Q

Gene Ontology

No Gene Ontology data available.

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.