Search Results

Overview

Uniprot IDA0A286XTF0
Protein NameMAP kinase-activating death domain protein
Gene NameMADD
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
1392 INMTYCPKTKVLCLW

Function

Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis

Protein Sequence

10 MVQKKLCPRL 20 LDYLVIVGAR 30 HPSSDSVAQT 40 PELLRRYPLE 50 DHAEFPLPPD 60 VVFFCQPEGC 70 LSVRQRRMSL 80 RDDTSFVFTL 90 TDKDTGVTRY 100 GICVNFYRSF 110 QKRVPKEKGE 120 GGAGARGKEG 130 TRAAGATEEP 140 APETSESGPP 150 LQPPSSPQAK 160 RRAKGSGRSR 170 NSTLTSLCVL 180 SHYPFFSTFR 190 ECLYTLKRLV 200 DCCSERLLGK 210 KLGIPRGVQR 220 DTMWRIFTGS 230 LLVEEKSSAL 240 LHDLREIEAW 250 IYRLLRSPVP 260 VSGQKRVDVE 270 VLPQELQPPL 280 TFALPDPSRF 290 SLVDFPLHLP 300 LELLGVDACL 310 QVLTCILLEH 320 KVVLQSRDYN 330 ALSMSVMAFV 340 AMIYPLEYMF 350 PVIPLLPTCM 360 ASAEQLLLAP 370 TPYIIGVPAS 380 FFLYKLDFKM 390 PDDVWLVDLD 400 SNRVIAPTNA 410 EMLPILPEPE 420 SLELKKHLKQ 430 ALASMSLNTQ 440 PILNLEKFHE 450 GQEIPLLLGR 460 PSNDLQSTPS 470 TEFNPLIYGN 480 DVDSVDVATR 490 VAMVRFFNSA 500 NVLQGFQMHT 510 RTLRLFPRPV 520 VAFQAGSFLA 530 SRPRQTPFAE 540 KLARTQAVEY 550 FGEWILNPTN 560 YAFQRIHNNM 570 FDPALIGDKP 580 KWYAHQLQPI 590 HYRVYDGNSQ 600 LAEALSVPPE 610 RDSDSDPTDD 620 SGSDSMDYDD 630 SSSSYSSLGD 640 FVSEMMKCDI 650 NGDTPNVDPL 660 THAALGDASE 670 VAIDELQNQK 680 EVEEPGPEGE 690 NTQENPALRS 700 SCSTTASSSP 710 STVIHGANPV 720 RKDSGDSMGM 730 DRRQAESREG 740 SVCHRACDSP 750 YLESQYGLPP 760 EEDEDEQGEH 770 YTPHFSQHVD 780 GSRAQKLLRP 790 NSLKLASDSD 800 AESDSRASSP 810 TSTVSNTSST 820 EGFGGIMSFA 830 SKCLNPVVPP 840 VYPRCGAELP 850 SSSAQSGNRR 860 ALVDQKSSVI 870 KHSPTVKREP 880 PSPQGRSSNS 890 SENQQFLKEV 900 VHSVLDGQGV 910 GWLNMKKVRR 920 LLESEQLRVF 930 VLSKLNRVTQ 940 SEDESRQDII 950 PDVEISRKVY 960 KGMLDLLKCT 970 VLSLEQTYAH 980 AGLGGMASIF 990 GLLEIAQTHY 1000 YSKEPDKRKR 1010 SPTESVNTPV 1020 GKDPCLAGRG 1030 DPKAMVQLRV 1040 PQLGPRAPST 1050 TGKGPKEPDT 1060 RSLKEENFVA 1070 SVGPEVIKPA 1080 FDLGETEEKK 1090 SQISADSGVS 1100 LTSASQTTDR 1110 DSVIGVSPAV 1120 LIRSSSQDSE 1130 VSTVVSNSSG 1140 ETLGADSDLS 1150 SNAGDGPGGE 1160 GSAHLASSRG 1170 TLSDSEIETN 1180 SATSSIFGKA 1190 HSLKPKEKLA 1200 GSPVRSSEDV 1210 SQRVYLYEGL 1220 LGKERSTLWD 1230 QMQFWEDAFL 1240 DAVMLEREGM 1250 GMDQGPQEMI 1260 DRYLSLGDHD 1270 RKRLEDDEDR 1280 LLATLLHNLI 1290 SYMLLMKVNK 1300 NDIRKKVRRL 1310 MGKSHIGLVY 1320 SQQINEVLDQ 1330 LATLNGRDLS 1340 IRSSGSRHMK 1350 KQTFVVHAGT 1360 DTNGDIFFME 1370 VCDDCVVLRS 1380 NIGTVYERWW 1390 YEKLINMTYC 1400 PKTKVLCLWR 1410 RNGSETQLNK 1420 FYTKKVPGVS 1430 GLGRPELGGE 1440 FPVQDMKTGE 1450 GGLLQVTLEG 1460 INLKFMHNQV 1470 FIELNHIKKC 1480 NTVRGVFVLE 1490 EFVPEIKEVV 1500 SHKYKTPMAH 1510 EICYSVLCLF 1520 SYVAAVRSSE 1530 EDLRTPPRPV SS

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0006915 apoptotic process
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0032483 regulation of Rab protein signal transduction

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.