Search Results
Overview
| Uniprot ID | A0A286XU90 |
|---|---|
| Protein Name | LIM and SH3 domain protein 1 |
| Gene Name | LASP1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | KYHEEFEKSRMGPSG |
| 27 | NYKGYEKKPYCNAHY |
| 64 | LQSQVRYKEEFEKNK |
| 69 | RYKEEFEKNKGKGFS |
| 73 | EFEKNKGKGFSVVAD |
| 89 | PELQRIKKTQDQISN |
Function
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
Protein Sequence
10
FWHKACFHCE
20
TCKMTLNMKN
30
YKGYEKKPYC
40
NAHYPKQSFT
50
MVADTPENLR
60
LKQQSELQSQ
70
VRYKEEFEKN
80
KGKGFSVVAD
90
TPELQRIKKT
100
QDQISNIKYH
110
EEFEKSRMGP
120
SGGEGVEPDR
130
RDAQDSGTYR
140
RPPEQQPHHI
150
PTSAPVYQQP
160
QPQQQQQQVT
170
PSYVAPVAPG
180
SVQRSTPGGG
190
GKRYRAVYDY
200
SAADEDEVSF
210
QDGDTIVNVQ
220
QIDDGWMYGT
230
VERTGDTGML
PANYVEAI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006811 | monoatomic ion transport |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.