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Overview

Uniprot IDA0A286XV88
Protein NameSmall nuclear ribonucleoprotein G
Gene NameSnrpg
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
3 *****MSKAHPPELK

Function

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing

Protein Sequence

10 MSKAHPPELK 20 KFMDKKLSLK 30 LNGGRHVQGI 40 LRGFDPFMNL 50 VIDECVEMAT 60 SGQQNNIGMV 70 VIRGNSIIML EALERV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0034709 methylosome
Cellular Component GO:0043186 P granule
Cellular Component GO:0034719 SMN-Sm protein complex
Cellular Component GO:0005685 U1 snRNP
Cellular Component GO:0005689 U12-type spliceosomal complex
Cellular Component GO:0005686 U2 snRNP
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Cellular Component GO:0071004 U2-type prespliceosome
Cellular Component GO:0005687 U4 snRNP
Cellular Component GO:0046540 U4/U6 x U5 tri-snRNP complex
Cellular Component GO:0005682 U5 snRNP
Cellular Component GO:0005683 U7 snRNP
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000387 spliceosomal snRNP assembly

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.