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Overview

Uniprot IDA0A286XVA7
Protein NameProteasome subunit beta
Gene NamePSMB2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
162 KAVELLRKCLEELQK

Function

Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Protein Sequence

10 MEYLIGIQGP 20 DYVLVASDRV 30 AASSIVQMKD 40 DHDKMFKMSE 50 KILLLCVGEA 60 GDTVQFAEYI 70 QKNVQLYKMR 80 NGYELSPTAA 90 ANFTRRNLAD 100 CLRSRTPYHV 110 NLLLAGYDEH 120 EGPALYYMDY 130 LAALAKAPFA 140 AHGYGAFLTL 150 SILDRYYTPT 160 ISRDKAVELL 170 RKCLEELQKR 180 FILNLPTFSV 190 RIIDKNGIHD 200 LDNISFPKQG S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005839 proteasome core complex
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.