Search Results
Overview
| Uniprot ID | A0A286XVD2 |
|---|---|
| Protein Name | NEDD8-conjugating enzyme UBC12 |
| Gene Name | UBE2M |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MIKLFSLKQQKKEEE |
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation
Protein Sequence
10
MIKLFSLKQQ
20
KKEEESAGGT
30
KGSSKKASAA
40
QLRIQKDINE
50
LNLPKTCDIS
60
FSDPRRPPNF
70
KLVICPMEGF
80
YKSGKFVFSF
90
KVGQGYPHAP
100
PKVKCETMVY
110
HPNIALEGNV
120
CLNILREDWK
130
PVLTINSIIY
140
GLQYLFLEPN
150
PEDPLNKEAA
160
EVLQNNRRLF
170
EQNVQRSMRG
180
GYIGSIYFER
CLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061654 | NEDD8 conjugating enzyme activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Biological Process | GO:0045116 | protein neddylation |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.