Search Results

Overview

Uniprot IDA0A286XVM2
Protein NamemRNA cap guanine-N(7) methyltransferase
Gene NameRNMT
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
103 GDADSFSKKRKMETD
106 DSFSKKRKMETDGVP
121 SIGDSTQKKRKLELD
124 DSTQKKRKLELDDVP
133 ELDDVPEKQKKLEEG
61 DIARKKKKFEDSHVE
80 CGEDPPSKKRNLGIE

Function

Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC

Protein Sequence

10 MENSTKSEEC 20 EKLSFEEVKA 30 SVDCETKSSL 40 NINETSTASG 50 TGLSEKTPVC 60 EQVDIARKKK 70 KFEDSHVEES 80 SSCGEDPPSK 90 KRNLGIEIVP 100 EEKGSGDADS 110 FSKKRKMETD 120 GVPSIGDSTQ 130 KKRKLELDDV 140 PEKQKKLEEG 150 HSSAVAAHYN 160 ELQEVGLEKR 170 SQSRIFYLRN 180 FNNWIKSVLI 190 GEFLEKVRQK 200 KTRDITVLDL 210 GCGKGGDLLK 220 WRKGRISKLV 230 CTDIADISVK 240 QCQQRYEDMK 250 NRRDNEYLFH 260 AEFITADSSK 270 ELLVDKFCDP 280 EMCFDICSCQ 290 FVCHYSFESA 300 EQADMMLRNA 310 CERLSPGGYF 320 IGTTPNSFEL 330 IRRLEASETE 340 SFGNEIYTVK 350 FHKKGDYPLF 360 GCKYDFNLEG 370 VVDVPEFLVY 380 FPLLTQMVKK 390 YNMKLIYRKT 400 FMEFFEEKIK 410 NNENKMLLKR 420 MQALEPYPAN 430 ENSKLTSEKA 440 GDYEHAAAYM 450 KNSQVRLPLG 460 TLSKSEWEAT 470 SIYLVFAFEK QQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0160130 mRNA cap methyltransferase RNMT:RAMAC complex
Cellular Component GO:0031533 mRNA capping enzyme complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0043235 receptor complex
Molecular Function GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Function GO:0003723 RNA binding

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.