Overview
| Uniprot ID | A0A286XVP4 |
|---|
| Protein Name | Proteasome subunit alpha type |
|---|
| Gene Name | PSMA6 |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 181 |
ESTSFLEKKVKKKFD |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MSRGSSAGFD
20
RHITIFSPEG
30
RLYQVEYAFK
40
AINQGGLTSV
50
AVRGKDCAVI
60
VTQKKVPDKL
70
LDSSTVTHLF
80
KITENIGCVM
90
TGMTADSRSQ
100
VQRARYEAAN
110
WKYKYGYEIP
120
VDMLCKRIAD
130
ISQVYTQNAE
140
MRPLGCCMIL
150
IGIDEEQGPQ
160
VYKCDPAGYY
170
CGFKATAAGV
180
KQTESTSFLE
190
KKVKKKFDWT
200
FEQTVEIAIT
210
CLSTVLSIDF
220
KPSEIEVGVV
230
TVENPKFRIL
240
TEAEIDAHLV
ALAERD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097542 |
ciliary tip |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0000932 |
P-body |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Cellular Component |
GO:0005840 |
ribosome |
| Cellular Component |
GO:0097229 |
sperm end piece |
| Molecular Function |
GO:0051059 |
NF-kappaB binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0050727 |
regulation of inflammatory response |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.