Search Results
Overview
| Uniprot ID | A0A286XYN2 |
|---|---|
| Protein Name | Malate dehydrogenase |
| Gene Name | MDH1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | MERKDLLKANVKIFK |
| 110 | KANVKIFKSQGAALD |
| 118 | SQGAALDKYAKKSVK |
| 205 | AKVKLHGKEVGVYEA |
| 214 | VGVYEALKDDSWLKG |
| 236 | QRGAAVIKARKLSSA |
| 239 | AAVIKARKLSSAMSA |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MSEPIRVLVT
20
GAAGQIAYSL
30
LYSIGNGSVF
40
GKDQPIVLVL
50
LDITPMMGVL
60
DGVLMELQDC
70
ALPLLKDVIA
80
TDKEEVAFKD
90
LDVAVLVGSM
100
PRREGMERKD
110
LLKANVKIFK
120
SQGAALDKYA
130
KKSVKVIVVG
140
NPANTNCLTA
150
SKSAPSIPKE
160
NFSCLTRLDH
170
NRAKSQIALK
180
LGVTADDVKN
190
VIIWGNHSST
200
QYPDVNHAKV
210
KLHGKEVGVY
220
EALKDDSWLK
230
GDFITTVQQR
240
GAAVIKARKL
250
SSAMSAAKAI
260
ADHIRDIWFG
270
TPEGEFVSMG
280
VISDGNSYGI
290
PDDLLYSFPV
300
VIKNKTWKFV
310
EGLPINDFSR
320
EKMDITAKEL
330
AEEKETAFEF
LSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0047995 | (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity |
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.