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Overview

Uniprot IDA0A286XZC7
Protein NameNuclear receptor coactivator
Gene NameNCOA2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
639 HDSKGQTKLLQLLTT

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer

Protein Sequence

10 MSGMGENTSD 20 PARAETRKRK 30 ECSDQLGPSP 40 KRSTEKRNRE 50 QENKYIEELA 60 ELIFANFNDI 70 DNFNFKPDKC 80 AILKETVKQI 90 RQIKEQEKAA 100 AANIDEVQKS 110 DVSSTGQGVI 120 DKDALGPMML 130 EALDGFFFVV 140 NLEGNVVFVS 150 ENVTQYLRYN 160 QEELMNKSVY 170 SILHVGDHTE 180 FVKNLLPKSI 190 VNGGSWSGEP 200 PRRNSHTFNC 210 RMLVKPLPES 220 EEEGHDNQEA 230 HQKYETMQCF 240 AVSQPKSIKE 250 EGEDLQSCLI 260 CVARRVPMKE 270 RPVLPSSESF 280 TTRQDLQGKI 290 TSLDTSTMRA 300 AMKPGWEDLV 310 RRCIQKFHAQ 320 HEGESVSYAK 330 RHHHEVLRQG 340 LAFSQIYRFS 350 LSDGTLVAAQ 360 TKSKLIRSQT 370 TNEPQLVISL 380 HMLHREQNPC 390 MNPDLTGQAM 400 GKPLNPISSS 410 SPAHQAMCSG 420 NPGQDMTLSS 430 NINFPINGPK 440 EQMGMPMGRF 450 GGSGGMNHVS 460 GMQATTPQGS 470 NYALKMNSPS 480 QSSPGMNPGQ 490 PNSMLSPRHR 500 MSPGVAGSPR 510 IPPSQFSPAG 520 SLHSPVGVCS 530 STGNSHSYTN 540 SSLNALQALS 550 EGHGVSLGSS 560 LASPDLKMGN 570 LQNSPVNMNP 580 PPLSKMGSLD 590 SKDCFGLYGE 600 PSEGTTGQAE 610 SSCHPGEQKE 620 TNDSSISQAA 630 SGERAEGQNR 640 LHDSKGQTKL 650 LQLLTTKSDQ 660 MEPSPLPNSL 670 SDTNKDSTGS 680 LPSSGSTHGT 690 SLKEKHKILH 700 RLLQDSSSPV 710 DLAKLTAEAT 720 GKELSQESST 730 TAPGSEVTIK 740 QEPVSPKKKE 750 NALLRYLLDK 760 DDTKDIGLPE 770 ITPKLERLDS 780 KTDPASNTKL 790 IAMKTEKEEM 800 SFEPSDQPGS 810 ELDNLEEILD 820 DLQNSQLPQL 830 FPDTRPGAPA 840 GSVDKQAIIN 850 DLMQLTAENS 860 PVTPVGAQKT 870 ALRISQSRMM 880 GSNASRPTMP 890 SGEWASQSSA 900 VRVTCAATTS 910 AINRPIQGGM 920 IRNPTTSIPM 930 RPSSQPGQRQ 940 MLQSQVMNLG 950 PSELEMNMGA 960 PQYSQQQAPP 970 NQTAPWPESI 980 LPIDQTSFAS 990 QNRQPFGSSD 1000 DLLCPHPAAE 1010 SPSDEGALLD 1020 QLYLALRNFD 1030 GLEEIDRALG 1040 IPELVSQSQA 1050 VDPEQFSSQD 1060 SNIMLEQKAP 1070 VFPQQYASQA 1080 QIAQGSYTPM 1090 QDPNFHTMGQ 1100 RPSYATLRMQ 1110 PRPGLRPTGL 1120 VQNQPNQLRL 1130 QLQHRLQAQQ 1140 NRQPLMNQIS 1150 NVSNVNLTLR 1160 PGVPTQAPIN 1170 AQMLAQRQRE 1180 ILNQHLRQRQ 1190 MHQQQQVQQR 1200 TLMMRGQGLN 1210 MTPSMVAPSG 1220 IPATMSNPRI 1230 PQANAQQFPF 1240 PPNYGISQQP 1250 DPGFTGATTP 1260 QSPLMSPRMA 1270 HTQSPMMQQS 1280 QANPAYQAPS 1290 DMNGWAQGNM 1300 GGNSMFSQQS 1310 PPHFGQQANT 1320 SMYNNNMNIS 1330 VSMATNTGGM 1340 SSMNQMTGQI 1350 SMTSVTSVPT 1360 SGLSSMGPEQ 1370 VNDPALRGGS 1380 LFPNQLPGMD 1390 MIKQEGDASR KYC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0048511 rhythmic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.