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Overview

Uniprot IDA0A286XZN1
Protein NameNon-histone chromosomal protein HMG-17
Gene NameHmgn2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
31 RSARLSAKPAPPKPE
40 APPKPEPKPKKAPAK
82 AKTDQAQKAEGAGDA

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation

Protein Sequence

10 MPKRKAEGDA 20 KGDKAKVKDE 30 PQRRSARLSA 40 KPAPPKPEPK 50 PKKAPAKKGE 60 KVPKGKKGKA 70 DASKDGNNPA 80 ENGDAKTDQA 90 QKAEGAGDAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031492 nucleosomal DNA binding
Biological Process GO:0006325 chromatin organization

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.