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Overview

Uniprot IDA0A286XZS3
Protein NameGeneral transcription factor II-I
Gene NameGTF2I
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
130 CYGKALGKSTVVPVP
192 QRPFLEPKKHLGGRV
219 SGSCGPVKVKTEPTE
267 VREFNFEKWNARITD
475 PRTNTPVKEDWNVRI
578 MASKINTKALQSPKR
584 TKALQSPKRPRSPGS

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSTLP 20 IEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKSTAQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVVV 160 QGLPEGVAFK 170 HPENYDLATL 180 KWILENKAGI 190 SFIIQRPFLE 200 PKKHLGGRVM 210 VTDTERSIMS 220 PSGSCGPVKV 230 KTEPTEDSDD 240 DYSPPTKRPK 250 SSEPPQPPVA 260 EPANAGKRKV 270 REFNFEKWNA 280 RITDLRKQVE 290 ELFERKYAQA 300 IKAKGPVTIP 310 YPLFQSHVED 320 LYVEGLPEGI 330 PFRRPSTYGI 340 PRLERILLAK 350 ERIRFVIKKH 360 ELLNSTREDL 370 QLDKPASGVK 380 EEWYARITKL 390 RKMVDQLFCK 400 KFAEALGSTE 410 AKAVPYQKFE 420 AHPNDLYVEG 430 LPENIPFRSP 440 SWYGIPRLEK 450 IIQVGNRIKF 460 VIKRPELLTH 470 STTEVTQPRT 480 NTPVKEDWNV 490 RITKLRKQVE 500 EIFNLKFAQA 510 LGLTEAVKVP 520 YPVFESNPEF 530 LYVEGLPEGI 540 PFRSPTWFGI 550 PRLERIVRGS 560 NKIKFVVKKP 570 ELVVSYLPPG 580 MASKINTKAL 590 QSPKRPRSPG 600 SNSKVPEIEV 610 TVEGPNNNNP 620 QTSTVRTPTQ 630 TNGSNVPFKP 640 RGREFSFEAW 650 NAKITDLKQK 660 VENLFNEKCG 670 EALGLKQAVK 680 VPFALFESFP 690 EDFYVEGLPE 700 GVPFRRPSTF 710 GIPRLEKILR 720 NKAKIKFIIK 730 KPEMFETAIK 740 ESTSSKSPPR 750 KINSSPSVNT 760 TASGVEDLNI 770 IQVTIPDDDN 780 ERLSKVEKAR 790 QLREQVNDLF 800 SRKFGEAIGM 810 GFPVKVPYRK 820 ITINPGCVVV 830 DGMPPGVSFK 840 APSYLEISSM 850 RRILDSAEFI 860 KFTVIRPFPG 870 LVINNQLVDQ 880 NESEGPVIQE 890 SAESTQLEVP 900 PTEEIKETEG 910 SSQIKQEPDP TW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.