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Overview

Uniprot IDA0A286Y0N3
Protein NameCreatine kinase B-type
Gene NameCKB
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
242 LRVISMQKGGNMKEV
247 MQKGGNMKEVFTRFC
304 IKLPHLGKHEKFPEV
307 PHLGKHEKFPEVLKR
313 EKFPEVLKRLRLQKR

Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work

Protein Sequence

10 MPFSNSHNAM 20 KMNFPAEDEY 30 PDLSRHNNHM 40 AKVLTPELYA 50 ELRAKSTPSG 60 FTLDDVIQTG 70 VDNPGHPFIM 80 TVGCVAGDEE 90 SYDVFKALFD 100 PIIEDRHGGY 110 QPSDEHKTDL 120 NPDNLQGGDD 130 LDPNYVLSSR 140 VRTGRSIRGF 150 CLPPHCSRGE 160 RRAIEKLAVE 170 ALSSLDGDLA 180 GRYYALKSMT 190 EAEQQQLIDD 200 HFLFDKPVSP 210 LLLASGMARD 220 WPDARGIWHN 230 DNKTFLVWVN 240 EEDHLRVISM 250 QKGGNMKEVF 260 TRFCTGLTQI 270 ETLFKSKNYE 280 FMWNPHLGYI 290 LTCPSNLGTG 300 LRAGVHIKLP 310 HLGKHEKFPE 320 VLKRLRLQKR 330 GTGGVDTAAV 340 GGVFDVSNAD 350 RLGFSEVELV 360 QMVVDGVKLL 370 IEMEQRLEQG 380 QAIDDLVPAQ K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004111 creatine kinase activity
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0140651 futile creatine cycle
Biological Process GO:0046314 phosphocreatine biosynthetic process

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.