Search Results
Overview
| Uniprot ID | A0A286Y0R6 |
|---|---|
| Protein Name | Prefoldin subunit 2 |
| Gene Name | PFDN2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | SSGSGAGKGAVSAEQ |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins
Protein Sequence
10
MAESSGRAGK
20
SSGSGAGKGA
30
VSAEQVIAGF
40
NRLRQEQRGL
50
ASKAAELEME
60
LNEHSLVIDT
70
LKEVDETRKC
80
FRMVGGVLVE
90
RTVKEVLPAL
100
ENNKEQIQKI
110
IETLTQQLQA
120
KGKELNEFRE
130
KHNIRLMGED
140
EKPAAKENSE
150
GAGAKASSAG
VLVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0016272 | prefoldin complex |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0051495 | positive regulation of cytoskeleton organization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.