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Overview

Uniprot IDA0A286Y0Z3
Protein NameTelomeric repeat-binding factor 2
Gene NameTERF2
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
287 TMAKKSLKSESVVSS
444 SHACPGEKNPKVSKG

Function

No function data available.

Protein Sequence

10 MAAGAGTAGS 20 ASGPGVVRDP 30 TASQPRKRPS 40 REGGESARRS 50 DVMAGGGGSS 60 EGSGRAGGRR 70 TSRSSGRARR 80 GRHESGLGGA 90 AERGAGEARL 100 EEAVNRWVLK 110 FYFHEALRAF 120 RSSRYADFRQ 130 IRDIMQALLV 140 RPLGKEHTVS 150 RLLRVMQCLS 160 RIEEGENLDC 170 SFDMEAELTP 180 LESAMNVLEM 190 IKTEFTLTEA 200 MVESSRKLVK 210 EAAVIICIKN 220 KEFEKASKIL 230 KKHMSKDPST 240 QKLRSDLLNI 250 IREKNLAHPV 260 IQNFSYEIFQ 270 QKMLRFLESH 280 LDGTEPYLLT 290 MAKKSLKSES 300 VVSSAVKEDK 310 QPAPQPVEKP 320 LREPARQLQN 330 TPTTIGIRTL 340 KAAFKALSGA 350 QDSEAAFSKL 360 DQKDLVLPNQ 370 APPSSPALKT 380 KRPRKDENEN 390 ANSSPAEGEG 400 SSELQPKNKR 410 MTISRLILEE 420 DSQNQSTEPN 430 PGLSSSPEVA 440 SKSTALSHAC 450 PGEKNPKVSK 460 GKWNSSNGVE 470 EKETWIGEDE 480 LFQVQGATGE 490 DSTTSVARKQ 500 KWTVEESEWV 510 KAGVQKYGEG 520 NWVAISKNYP 530 FVNRTAVMIK 540 DRWRTMKKLG MN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001673 male germ cell nucleus
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0070187 shelterin complex
Molecular Function GO:0003691 double-stranded telomeric DNA binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0098505 G-rich strand telomeric DNA binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003720 telomerase activity
Biological Process GO:2000773 negative regulation of cellular senescence
Biological Process GO:1904430 negative regulation of t-circle formation
Biological Process GO:1904354 negative regulation of telomere capping
Biological Process GO:0032208 negative regulation of telomere maintenance via recombination
Biological Process GO:0032211 negative regulation of telomere maintenance via telomerase
Biological Process GO:1905839 negative regulation of telomeric D-loop disassembly
Biological Process GO:0032206 positive regulation of telomere maintenance
Biological Process GO:0031848 protection from non-homologous end joining at telomere
Biological Process GO:0070198 protein localization to chromosome, telomeric region
Biological Process GO:0061820 telomeric D-loop disassembly
Biological Process GO:0031627 telomeric loop formation

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.