Search Results
Overview
| Uniprot ID | A0A286Y183 |
|---|---|
| Protein Name | High mobility group protein HMG-I/HMG-Y |
| Gene Name | HMGA1 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | RGRGRPRKQPPVSPG |
| 55 | PSEVPTPKRPRGRPK |
| 7 | *MSESSSKSSQPLAS |
Function
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions
Protein Sequence
10
MSESSSKSSQ
20
PLASKPEKDG
30
TEKRGRGRPR
40
KQPPVSPGTA
50
LVGSQKEPSE
60
VPTPKRPRGR
70
PKGSKNKGAA
80
KIRKTTTAPG
90
RKPRGRPKKL
100
EKVEEEEGIS
QESSEEEQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0035985 | senescence-associated heterochromatin focus |
| Cellular Component | GO:0106068 | SUMO ligase complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0062037 | D-loop DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0046965 | nuclear retinoid X receptor binding |
| Molecular Function | GO:0042975 | peroxisome proliferator activated receptor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0090402 | oncogene-induced cell senescence |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.