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Overview

Uniprot IDA0A286Y1Z7
Protein NameCell division control protein 42 homolog
Gene NameCDC42
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
133 IEKLAKNKQKPITPE

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state

Protein Sequence

10 MQTIKCVVVG 20 DGAVGKTCLL 30 ISYTTNKFPS 40 EYVPTVFDNY 50 AVTVMIGGEP 60 YTLGLFDTAG 70 QEDYDRLRPL 80 SYPQTDVFLV 90 CFSVVSPSSF 100 ENVKEKWVPE 110 ITHHCPKTPF 120 LLVGTQIDLR 130 DDPSTIEKLA 140 KNKQKPITPE 150 TAEKLARDLK 160 AVKYVECSAL 170 TQKGLKNVFD 180 EAILAALEPP 190 EPKKSRRCVL L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030175 filopodium
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0017119 Golgi transport complex
Cellular Component GO:0031256 leading edge membrane
Cellular Component GO:0030496 midbody
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0051233 spindle midzone
Cellular Component GO:0000322 storage vacuole
Molecular Function GO:0034191 apolipoprotein A-I receptor binding
Molecular Function GO:0003925 G protein activity
Molecular Function GO:0032427 GBD domain binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0030742 GTP-dependent protein binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0031996 thioesterase binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
Biological Process GO:0034329 cell junction assembly
Biological Process GO:0060997 dendritic spine morphogenesis
Biological Process GO:0035050 embryonic heart tube development
Biological Process GO:0086100 endothelin receptor signaling pathway
Biological Process GO:0045198 establishment of epithelial cell apical/basal polarity
Biological Process GO:0003015 heart process
Biological Process GO:0044788 host-mediated perturbation of viral process
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0031333 negative regulation of protein-containing complex assembly
Biological Process GO:0038189 neuropilin signaling pathway
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
Biological Process GO:0051491 positive regulation of filopodium assembly
Biological Process GO:0010592 positive regulation of lamellipodium assembly
Biological Process GO:0048549 positive regulation of pinocytosis
Biological Process GO:0031274 positive regulation of pseudopodium assembly
Biological Process GO:0051496 positive regulation of stress fiber assembly
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Biological Process GO:0099175 regulation of postsynapse organization
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.