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Overview

Uniprot IDA0A286Y485
Protein NameMultifunctional fusion protein
Gene NameSNAP25
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
178 QIDRIMEKADSNKTR

Function

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells

Protein Sequence

10 MRNELEEMQR 20 RADQLADESL 30 ESTRRMLQLV 40 EESKDAGIRT 50 LVMLDEQGEQ 60 LERIEEGMDQ 70 INKDMKEAEK 80 NLTDLGKFCG 90 LCVCPCNKLK 100 SSDAYKKAWG 110 NNQDGVVASQ 120 PARVVDEREQ 130 MAISGGFIRR 140 VTNDARENEM 150 DENLEQVSGI 160 IGNLRHMALD 170 MGNEIDTQNR 180 QIDRIMEKAD 190 SNKTRIDEAN 200 QRATKMLGSG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Molecular Function GO:0005484 SNAP receptor activity
Molecular Function GO:0017075 syntaxin-1 binding
Molecular Function GO:0005249 voltage-gated potassium channel activity
Biological Process GO:0048791 calcium ion-regulated exocytosis of neurotransmitter
Biological Process GO:0070201 regulation of establishment of protein localization
Biological Process GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
Biological Process GO:0016082 synaptic vesicle priming

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.