Overview
| Uniprot ID | A0A286Y4L7 |
|---|
| Protein Name | Src substrate cortactin |
|---|
| Gene Name | CTTN |
|---|
| Organism | Cavia porcellus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 107 |
VGHEYQSKLAKHCSQ |
| 124 |
SVRGFGGKFGVQMDR |
| 144 |
VGFEYQGKTEKHASQ |
| 161 |
YSSGFGGKYGVQADR |
| 181 |
VGFDYQGKTEKHESQ |
| 198 |
YSKGFGGKYGIDKDK |
| 208 |
IDKDKVDKSAVGFEY |
| 235 |
YVKGFGGKFGVQTDR |
| 272 |
YSKGFGGKYGVQKDR |
| 45 |
RWGAKTVKGSGHQEH |
| 57 |
QEHINIHKLRENVFQ |
| 87 |
ASHGYGGKFGVEQDR |
Function
Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane
Protein Sequence
10
MWKASAGHAV
20
SITQDVGGAD
30
DWETDPDFVN
40
DVSEKEQRWG
50
AKTVKGSGHQ
60
EHINIHKLRE
70
NVFQEHQTLK
80
EKELETGPKA
90
SHGYGGKFGV
100
EQDRMDKSAV
110
GHEYQSKLAK
120
HCSQVDSVRG
130
FGGKFGVQMD
140
RVDQSAVGFE
150
YQGKTEKHAS
160
QKDYSSGFGG
170
KYGVQADRVD
180
KSAVGFDYQG
190
KTEKHESQKD
200
YSKGFGGKYG
210
IDKDKVDKSA
220
VGFEYQGKTE
230
KHESQKDYVK
240
GFGGKFGVQT
250
DRQDKCALGW
260
DHQEKLQLHE
270
SQKDYSKGFG
280
GKYGVQKDRM
290
DKNASTFEDV
300
AQVSSAYQKT
310
VPVEAVTSKT
320
SNIRANFENL
330
AKEREQEDRR
340
KVEAERAQRM
350
AKERKEQEEA
360
RRKLEEQARE
370
KKETPTESPT
380
PQPAEERQPS
390
SPVYEDAASL
400
KAEVSHRGPA
410
SESEPEPAYI
420
AESTSYPEAI
430
SQQGLGYDLE
440
AVYDTTKASG
450
HYQAEENTYD
460
EYENDLGITA
470
IALYDYQAAG
480
DDEISFDPDD
490
IISNIEMIDD
500
GWWRGVCKGR
510
YGLFPANYVE
LRQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005884 |
actin filament |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0030864 |
cortical actin cytoskeleton |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0002102 |
podosome |
| Cellular Component |
GO:0001726 |
ruffle |
| Cellular Component |
GO:0030427 |
site of polarized growth |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.