Search Results
Overview
| Uniprot ID | A0A286Y4Y3 |
|---|---|
| Protein Name | Aspartate aminotransferase |
| Gene Name | GOT2 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 338 | LTSPDLRKQWLQEVK |
| 363 | TQLVSNLKKEGSSHN |
| 404 | EFSIYMTKDGRISVA |
| 90 | AEAQLAAKNVDKEYL |
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids
Protein Sequence
10
MALLHSSRVL
20
SGVAAAFHPG
30
LAAVASARAS
40
SWWTHVEMGP
50
PDPILGVTEA
60
YKRDTNSKKM
70
NLGVGAYRDD
80
NGKPYVLPSV
90
RKAEAQLAAK
100
NVDKEYLPIA
110
GLAEFCKASA
120
ELALGENNEV
130
LKSGRFVTVQ
140
TISGTGALRI
150
GANFLQRFFK
160
FSRDVYLPKP
170
SWGNHTPIFR
180
DAGMQLQGYR
190
YYDPKTCGFD
200
FTGAMEDISK
210
IPEQSIILLH
220
ACAHNPTGVD
230
PRQEQWKEIA
240
SVVKKKNLFA
250
FFDMAYQGFA
260
SGDGDRDAWA
270
VRHFIEQGIN
280
VCLCQSYAKN
290
MGLYGERVGA
300
FTVICKDADE
310
AKRVESQLKI
320
LIRPMYSNPP
330
INGARIASTI
340
LTSPDLRKQW
350
LQEVKGMADR
360
IISMRTQLVS
370
NLKKEGSSHN
380
WQHITDQIGM
390
FCFTGLKPEQ
400
VERLTKEFSI
410
YMTKDGRISV
420
AGVTSGNVGY
430
LAHAIHQVTK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0016212 | kynurenine-oxoglutarate transaminase activity |
| Molecular Function | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0043650 | dicarboxylic acid biosynthetic process |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0006536 | glutamate metabolic process |
| Biological Process | GO:0170034 | L-amino acid biosynthetic process |
| Biological Process | GO:0006533 | L-aspartate catabolic process |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
| Biological Process | GO:0170038 | proteinogenic amino acid biosynthetic process |
| Biological Process | GO:0045471 | response to ethanol |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.