Search Results
Overview
| Uniprot ID | A0A286Y523 |
|---|---|
| Protein Name | Splicing factor 45 |
| Gene Name | RBM17 |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | SKTEGWSKNFKLLQS |
| 24 | EGWSKNFKLLQSQLQ |
| 243 | VAHKIMQKYGFREGQ |
| 267 | STALSVEKTSKRGGK |
| 274 | KTSKRGGKIIVGDAT |
| 33 | LQSQLQVKKAALTQA |
| 41 | KAALTQAKSQRTKQS |
Function
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites
Protein Sequence
10
MSLYDDLGVE
20
TSDSKTEGWS
30
KNFKLLQSQL
40
QVKKAALTQA
50
KSQRTKQSTV
60
LAPVIDLKRG
70
GSGDDRQIVD
80
TPPHVAAGLK
90
DPVPSGFSAG
100
EVLIPLADEY
110
DPMFPNDYEK
120
VVKRQREERQ
130
RQRELERQKE
140
IEEREKRRKD
150
RHEASGFSRR
160
PDPDSDEDED
170
YERERRKRSK
180
TLLGGKANCP
190
GVFPALPRDF
200
PYEEDSRPRS
210
QSSKAAIPPP
220
VYEEQDRPRS
230
PTGPSNSFLA
240
NMGGTVAHKI
250
MQKYGFREGQ
260
GLGKHEQGLS
270
TALSVEKTSK
280
RGGKIIVGDA
290
TEKGESQDAS
300
KKSDSNPLTE
310
ILKCPTKVVL
320
LRNMVGAGEV
330
DEDLEIETKE
340
ECEKYGKVGK
350
CVIFEIPGAP
360
DDEAVRIFLE
370
FERVESAIKA
380
VVDLNGRYFG
390
GRVVKACFYN
400
LDKFRVLDLA
EQV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0000380 | alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0045292 | mRNA cis splicing, via spliceosome |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.