Search Results

Overview

Uniprot IDA0A286Y565
Protein NameLysine-specific demethylase
Gene NameKDM3B
OrganismCavia porcellus

Kla Sites from experimental identification

Position Flanking peptide
526 STLGADTKLGSKAGS
820 RPRTAPLKVGQSVLK

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code

Protein Sequence

10 MGFPKYDFHI 20 AFCLFMQIFV 30 EFDGCNWKQH 40 SWVKVHAEEV 50 IVLLLEGSLV 60 WAPRKDPRVS 70 IAQWPALTFT 80 PLVDKLGLGS 90 VVPVEYLLDR 100 ELRFLSDTTG 110 LHLFQMGTDS 120 QNQILLEHAA 130 LRETVNALIS 140 DQKLQEIFSR 150 GPYSVQGHRV 160 KVYQPEGEEG 170 WIYGIVSHQD 180 SITRLMEVSI 190 TESGEIKSVD 200 PRLIHVMLVD 210 SSTPQSEGGT 220 LKAVKSSKGK 230 KKRESIEGKD 240 GRRRKSASDS 250 GCDPSSKKLK 260 GDRGEVDSNG 270 NDGSEASRGP 280 WKEGNASGEP 290 GLDQRAKQPS 300 STFVPQINRN 310 IRFATYTKEN 320 GRTLVVQDEP 330 MGGDTPVSFT 340 PYSTATGQTP 350 LAPEVGGAEN 360 KEAGKTLEQV 370 GQGMVASAAV 380 VTTASSTPTT 390 VRISDSGLAT 400 GIGPEKQKGW 410 SQASGEISRN 420 SILGSSGFGA 430 SLPSLSQPLT 440 FGSGRNQSNG 450 VLITENKPLG 460 FSFGCGSAPE 470 AQKDSDLSKN 480 LFFQCMSQTL 490 PTSNYFTTVS 500 ESLADDSSSR 510 DSFKQSLESL 520 SSGLCKSRST 530 LGADTKLGSK 540 AGSSVDRKVP 550 AESMPTLTPA 560 FPRSLLNTRT 570 PESHENLFLQ 580 PPKLSREEPS 590 NPFLAFVEKV 600 EHSPFSSFAS 610 QASSSSATTV 620 TSKAAPSWPE 630 SHSSTDSTCL 640 TKKKPLFITT 650 DSSKLVPGVL 660 GSTLSTGSPS 670 LSAMGNGRSS 680 SPTSSLTQPI 690 EMPTLSSSPT 700 EERPTVGPGQ 710 QDNPLLKTFS 720 NVFGRHSGSF 730 LSSPADFSQE 740 NKAPFEAVKR 750 FSLDERSLAC 760 RQDSDSSTNS 770 DLSDLSDSEE 780 QLQAKTGLKG 790 IPEHLMGKLG 800 PNGERTAELL 810 LGKGKGKQTP 820 KGRPRTAPLK 830 VGQSVLKDVS 840 KVKKLKQSGE 850 PFLQDGSCIN 860 VAPHLHKCRE 870 CRLERYRKFK 880 EQEQDDSTVA 890 CRFFHFRRLI 900 FTRKGVLRVE 910 GFLSPQQSDP 920 DAMNLWIPSS 930 SLAEGIDLET 940 SKYILANVGD 950 QFCQLVMSEK 960 EAMMMVEPHQ 970 KVAWKRAVRG 980 VREMCDVCET 990 TLFNIHWVCR 1000 KCGFGVCLDC 1010 YRLRKSRPRS 1020 ETEEMGDEEV 1030 FSWLKCAKGQ 1040 SHEPENLMPT 1050 QIIPGTALYN 1060 IGDMVHAARG 1070 KWGIKANCPC 1080 ISRQNKSVLR 1090 PAVTNGMSQL 1100 PSINPSASSG 1110 NETTFSGGGG 1120 TATGTAPEPS 1130 HGPKGDGTDV 1140 RPEETLRADG 1150 SASNSNSELK 1160 AIRPPCPDTT 1170 PPSSALHWLA 1180 DLATQKAKEE 1190 TKEAGSLRSV 1200 LNKESHSPFG 1210 LDSFNSTAKV 1220 SPLTPKLFNS 1230 LLLGPTASNN 1240 KTEGSSLRDL 1250 LHSGPGKLPQ 1260 TPLDTGIPFP 1270 PVFSTSSAGV 1280 KSKASLPNFL 1290 DHIIASVVEN 1300 KKTSDASKRA 1310 CNVTDTQKEV 1320 KEMVMGLNVL 1330 DPHTSHSWLC 1340 DGRLLCLHDP 1350 SNKNNWKIFR 1360 ECWKQGQPVL 1370 VSGVHKKLKS 1380 ELWKPEAFSQ 1390 EFGDQDVDLV 1400 NCRNCAIISD 1410 VKVRDFWDGF 1420 EIICKRLRSE 1430 DGQPMVLKLK 1440 DWPPGEDFRD 1450 MMPTRFEDLM 1460 ENLPLPEYTK 1470 RDGRLNLASR 1480 LPSYFVRPDL 1490 GPKMYNAYGL 1500 ITAEDRRVGT 1510 TNLHLDVSDA 1520 VNVMVYVGIP 1530 IGEGAHDEEV 1540 LKTIDEGDAD 1550 EVTKQRIHDG 1560 NEKPGALWHI 1570 YAAKDAEKIR 1580 ELLRKVGEEQ 1590 GQENPPDHDP 1600 IHDQSWYLDQ 1610 TLRKRLYEEY 1620 GVQGWAIVQF 1630 LGDAVFIPAG 1640 APHQVHNLYS 1650 CIKVAEDFVS 1660 PEHVKHCFRL 1670 TQEFRHLSNT 1680 HTNHEDKLQV 1690 KNIIYHAVKD 1700 AVGTLKAHES KLARS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000118 histone deacetylase complex
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0140683 histone H3K9me/H3K9me2 demethylase activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0070988 demethylation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.