Search Results
Overview
| Uniprot ID | A0A286Y5N1 |
|---|---|
| Protein Name | Cyclin-dependent kinase inhibitor 1B |
| Gene Name | CDKN1B |
| Organism | Cavia porcellus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | RPPKGAGKVPPQESQ |
| 96 | YRPPRPPKGAGKVPP |
Function
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry
Protein Sequence
10
MSNVRVSNGS
20
PSLERMDARQ
30
PEHPKPSACR
40
NLFGPVNHEE
50
LTRDLEKHCR
60
DMEEASQRKW
70
NFDFQNHKPL
80
EGKYEWQEVE
90
KGSLPEFYYR
100
PPRPPKGAGK
110
VPPQESQDVS
120
GNRQAVPLIG
130
SQANSEDTHL
140
VDPKPDPSDS
150
QTGLAEQCAG
160
IRKRPATDDS
170
SSQNKRANRT
180
EENVSDGSPN
190
ATSVEQTPKK
PGLRRRQT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0030332 | cyclin binding |
| Molecular Function | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0048102 | autophagic cell death |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:1905179 | negative regulation of cardiac muscle tissue regeneration |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0045930 | negative regulation of mitotic cell cycle |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0051168 | nuclear export |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Feng J, Chen X, Li R, Xie Y, Zhang X et al.. Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia.. iScience 27(9):110606. 2024 Sep 20. PMID: 39246443.