Search Results
Overview
| Uniprot ID | A0A286ZHV7 |
|---|---|
| Protein Name | Basement membrane-specific heparan sulfate proteoglycan core protein |
| Gene Name | HSPG2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1418 | KVAAYGGKLRYSLSY |
| 1800 | VTFICTAKSKSPAYT |
| 1802 | FICTAKSKSPAYTLV |
| 365 | DEADCPVKRPEDVCG |
| 799 | GPQCNKCKAGFFGDA |
Function
Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6
Protein Sequence
10
MGRRAAGALL
20
LALLLQGRLL
30
AVSHGLRAYD
40
GLSLPEDAET
50
ISAGRAGWSY
60
SDLSDDEDFL
70
ADEASGDGVG
80
SGDLGSGDFQ
90
MVYFRALVNF
100
THSIDYSPQL
110
EDAGSEAFRE
120
VSEAVVDTLE
130
SEYLKIPGDQ
140
VVSVVFIKEL
150
DSWVFVELDV
160
GSEGNADGAQ
170
IQEVLHAVIS
180
SGSIASYVTS
190
PQGFQFRRLG
200
TVPQFSRVCT
210
EAEFACHRYN
220
ECVALEYRCD
230
RRPDCRDMSD
240
ELDCEEPVPV
250
LSSLPPTLAE
260
TPPLPPSPPE
270
PEAATARQLP
280
ATPAPQALFP
290
SPDKAAPCGP
300
HEATCRSGHC
310
IPKDYVCDGQ
320
EDCRDGSDEL
330
DCGPAPPCEP
340
NEFPCGNGHC
350
ALKLWRCDGD
360
FDCEDRTDEA
370
DCPVKRPEDV
380
CGPTQFRCVS
390
TNTCIPASFH
400
CDEESDCPDR
410
SDEFGCMPPQ
420
VVTPPQESIQ
430
ASRGQTVTFT
440
CVAIGVPTPI
450
INWRLNWGHI
460
PSHPRVTVTS
470
EGGRGTLIIR
480
DVKEADQGAY
490
TCEAMNARGM
500
VFGIPDGVLE
510
LIPQRGPCPD
520
GHFYLEQSAS
530
CLPCFCFGVT
540
NVCQSSRRFR
550
DKIRLRFDQP
560
NDFKGVNVTM
570
PSQPGMPPLS
580
STQLQIDAAL
590
QEFQLVDLSR
600
RFLVHDSFWA
610
LPEQFLGNKV
620
DSYGGFLHYK
630
VRYELARGTL
640
EPVQRPDVVL
650
VGAGHRLLSR
660
GHTPTQPGTL
670
NQRQVQFSEE
680
HWVHESGRPV
690
QRAEMLQVLQ
700
SLEAVLIQTV
710
YNAKMASVGL
720
SDISMDTTVT
730
YATSHGRAHS
740
VEECRCPIGY
750
SGLSCESCDA
760
HFTRVPGGPY
770
LGTCSGCSCN
780
GHASSCDPVY
790
GHCLNCQHNT
800
EGPQCNKCKA
810
GFFGDATKGT
820
ATACRPCPCP
830
YIDASRRFSD
840
TCFLDTDGQA
850
TCDACAPGYT
860
GRRCESCAPG
870
YEGNPIQPGG
880
KCRPTNQQIV
890
RCDERGSTGT
900
SGEACRCKNN
910
VVGRLCNECV
920
AGSFHLSARN
930
PDGCLKCFCM
940
GVSRQCTSSS
950
WSRAQVLGAS
960
EEPAQFSLTN
970
AAGTHTTSEG
980
ISSPTPGELA
990
FSSFHSLLSG
1000
PYFWSLPSRF
1010
LGDKVTSYGG
1020
ELRFTVTQRP
1030
QPGSVPLHGQ
1040
PLVVLQGNNI
1050
ILEHHTSQEP
1060
SPGQPSTFTV
1070
PFREQAWQRP
1080
DGQPATREHL
1090
LMALAGIDTL
1100
LIQASYTQRP
1110
AESRVSGISM
1120
DVAVPEDTGQ
1130
DPALEVEQCT
1140
CPPGYRGPSC
1150
QDCDTGYTRM
1160
PSGLYLGTCE
1170
RCSCHGHTEV
1180
CEPETGACQG
1190
CQHHTEGPRC
1200
EQCQPGYYGD
1210
AQRGTPQDCQ
1220
PCPCHGAPAA
1230
GQATHTCFLD
1240
TDGHPTCDAC
1250
SPGHSGRHCE
1260
RCAPGYHGNP
1270
SQGQPCRRDD
1280
GQVPEPISCS
1290
CDPQGSISNQ
1300
CDAAGQCQCK
1310
AQVEGLTCSH
1320
CRPHHFYLSA
1330
SNPDGCLPCF
1340
CMGVTQQCSS
1350
SSYTRHLIST
1360
RFAPGDFQGF
1370
ALVNPQRNSR
1380
LTGGFTVEPV
1390
PEGAQLSFGN
1400
FANLGHESFY
1410
WQLPETYQGD
1420
KVAAYGGKLR
1430
YSLSYTAGAQ
1440
GSPLSDPDVQ
1450
ITGNNIMLVA
1460
SQPALQGPER
1470
RSYEIIFREE
1480
FWRRPDGQPA
1490
TREHLLMALA
1500
DLDELLVRAT
1510
FSSMPLAASI
1520
SAVSLEVAQP
1530
GPSEGPRAPE
1540
VEECRCPPGY
1550
VGSSCQDCAP
1560
GYTRTGSGLY
1570
LGHCELCECN
1580
GHSDLCHPET
1590
GACSQCQHNA
1600
AGEFCELCAP
1610
GYYGDATAGT
1620
PEDCQPCACP
1630
LTNPENMFSR
1640
TCESLGAGGY
1650
RCTACEPGYT
1660
GQYCEQCAPG
1670
YVGNPNVRGG
1680
RCLPQADQAP
1690
LVVQVQPPRS
1700
VVPQGGPHSL
1710
RCQVSGSPPH
1720
YFYWSREDGR
1730
PLPSSTQQRH
1740
QGSELHFPSV
1750
QPSDAGVYIC
1760
TCRNLHHANT
1770
SRAELLVTEA
1780
PSKPITVTVE
1790
EQRSQSVRPG
1800
TDVTFICTAK
1810
SKSPAYTLVW
1820
TRLHNGKLPT
1830
RAMDFNGILT
1840
IRNVQPSDAG
1850
TYVCTGSNMF
1860
AMDQGTATLH
1870
VQASGTPSAP
1880
MASIHPPQLT
1890
VQPGQLAEFR
1900
CSATGNPTPT
1910
LEWTGGPGGQ
1920
LPQKAQILGG
1930
ILRLPAVEPS
1940
DQAQYLCHAH
1950
SSAGQHVARA
1960
VLHVHGGNGP
1970
RVQVSPERTQ
1980
VHEGRTVRLY
1990
CRAAGVPSAT
2000
ITWRKEGGSL
2010
PPQARSERTD
2020
IATLLIPAIT
2030
TADAGFYLCV
2040
ATSPAGTAQA
2050
RIQVVVLPAS
2060
GASSPPPVRI
2070
ESSSPSVTEG
2080
QTLDLNCVVT
2090
GLAYTQVTWY
2100
KRGGSLPPHA
2110
QVHGPRLRLS
2120
HVSPADSGEY
2130
VCRVENESGP
2140
KEASIIVSVL
2150
HSTHSAYTPA
2160
PGSTHPIRIE
2170
SSSSHVAEGQ
2180
TLDLNCVVPG
2190
QAHAQVTWHR
2200
RGGSLPARHQ
2210
THGSRLRLHQ
2220
VSPADSGEYV
2230
CRVVLGSGPL
2240
ESSVLVTIEA
2250
SDSGTGSIPR
2260
PIPPVRIESS
2270
SPTVAEGQTL
2280
DLNCVVAGQA
2290
HAQVTWYKRG
2300
GSLPARHQVR
2310
GSRLYIFQAS
2320
PADAGEYVCR
2330
ASNGVEATIT
2340
VTVTRTQGAN
2350
FAYPPGSTPI
2360
RIEPSSSHVA
2370
EGQTLDLNCV
2380
VPGQAHAQVT
2390
WHKRGGSLPA
2400
RHQTHGSLLR
2410
LYQVSPADSG
2420
EYVCRIVGGS
2430
VPLEASVLVT
2440
IEPADSVPAL
2450
GVTPPVRIES
2460
SSSHVAEGQT
2470
LDLNCLVSGQ
2480
AHAQVTWHKR
2490
GGSLPARHQV
2500
HGSRLRLPQV
2510
TPADSGEYVC
2520
RVVSSSGTQE
2530
ASVLVTIQQR
2540
LGPSRPQSVV
2550
YPVRIESSSD
2560
SLANGHTLDL
2570
NCLVASQAPH
2580
TITWYKRGGS
2590
LPSRHQIVGS
2600
RLRIPQVTPA
2610
DSGEYVCHVS
2620
NGAGSQETSL
2630
IVTIQGGGSS
2640
HVPSVSPPIR
2650
IESSSPTVVE
2660
GQTLDLTCVV
2670
AGQPQATITW
2680
YKRGGSLPAR
2690
HQAHGSHLRL
2700
HQMSVADSGE
2710
YVCRANNNID
2720
AQEASIVVSV
2730
SPSTRSPAVP
2740
GGAMPIRIES
2750
SSSHVAEGQT
2760
LDLNCVVPGQ
2770
AHAQVTWHKR
2780
GGSLPTHHQA
2790
HGSRLRLYQL
2800
SPADSGEYVC
2810
RVVSSSGPLE
2820
ASVLVTIEAS
2830
GSGTVLVPAA
2840
GGTPPIRIET
2850
SSSHVAEGQT
2860
LDLKCVVPGQ
2870
AHAQVTWHRR
2880
GGSLPARHQV
2890
HGPLLRLNQV
2900
SPADSGEYSC
2910
RVTGSSGTQE
2920
ASVLVTIEAS
2930
SPSPIPAPGL
2940
AQPIYIEASS
2950
SHVTEGQTLD
2960
LNCVVPGQAH
2970
AQVTWHKHGG
2980
SLPARHQTHG
2990
SRLRLHQVSQ
3000
ADSGEYVCRV
3010
VGISGPELEA
3020
SFTVTVPPSA
3030
GSSYRLRSPV
3040
ISIDPPSSTV
3050
QQGQDASFKC
3060
LIHDGAAPIS
3070
LEWKTRNQEL
3080
EDNVHISPNG
3090
SIITIVGTRP
3100
SNHGAYRCVA
3110
SNAYGVAQSV
3120
VTLSVHGPPT
3130
VSVLPEGPVR
3140
VKEGKAITLE
3150
CVSAGEPRSS
3160
ARWTRIGAPT
3170
NLEQRLHGLL
3180
DSHTLLQISS
3190
AKPSDAGIYV
3200
CLAQNALGTA
3210
QKRVEVIVDT
3220
GIMAPGAPQV
3230
QVEEAELTVE
3240
AGHTATLRCS
3250
ATGSPTPTIH
3260
WSKLRSPLPW
3270
QHQLEGDTLI
3280
IPRVAQQDSG
3290
QYICNATSPA
3300
GHAEATIALH
3310
VESPPYATTV
3320
PEHASVRAGE
3330
TVHLQCLAHG
3340
TPPLTFQWSR
3350
VGGNLPSRVT
3360
ARKEMLLFEP
3370
AAPEDSGRYR
3380
CRVTNKVGSA
3390
EAFAQVLVQG
3400
PSGSLPATPH
3410
PAGATPAVQV
3420
TPQLETKSIG
3430
ASVEFHCIVP
3440
SDQGTQLRWV
3450
KEGGQLPPGH
3460
SVHDGVLRIQ
3470
NLDQSCQGTY
3480
VCQAYGPWGQ
3490
AQASAQLVVQ
3500
ALPSVLINIR
3510
TSVQTVVVGH
3520
SVEFECLALG
3530
DPKPQVTWSK
3540
VGGPLRPGIV
3550
QTGGIVRIAH
3560
VELADAGQYR
3570
CTATNAAGTT
3580
QSHVLLLVQA
3590
LPQISTPPEV
3600
RVPAGSAAVF
3610
PCMASGYPTP
3620
DISWSKLDGN
3630
LPPDSRLENN
3640
MLLLPSVRPQ
3650
DAGTYVCTAT
3660
NRQGKVKAFA
3670
HLQVPERVVP
3680
YFTQTPHSFL
3690
PLPTIKDAYR
3700
KFEIKITFRP
3710
DSADGMLLYN
3720
GQKRIPGSPT
3730
NLANRQPDFI
3740
SFGLVGGRPE
3750
FRFDAGSGMA
3760
TIRHPTPLAL
3770
GQFHTVTLLR
3780
SLTQGSLIVG
3790
SLTPVNGTSQ
3800
GKFQGLDLNE
3810
ELYLGGYPDY
3820
GAIPKAGLSS
3830
GFVGCVRELR
3840
IQGEEIVFHD
3850
LNLTAHGISH
3860
CPTCRDRPCQ
3870
NGGHCQDSES
3880
SSYVCMCPAG
3890
FTGSRCEHSQ
3900
ALHCHPEACG
3910
PDATCVNRPD
3920
GRGYTCRCHL
3930
GRSGRRCEEG
3940
VTVTTPSMSG
3950
TGSYLALPAL
3960
TNTHHELRLD
3970
VEFKPLAPDG
3980
ILVFSGGQSG
3990
PVEDFVSLAM
4000
VGGHLEFRYE
4010
LGSGLAILRS
4020
SEPLALGRWH
4030
HVSAERFNKD
4040
GSLRVNGGRP
4050
VLRSSPGKSQ
4060
GLNLHTLLYL
4070
GGVEPSVQLP
4080
PATNVSAHFH
4090
GCIGEVSVNG
4100
KRLDLTYSFL
4110
GSRGIGQCYD
4120
SSPCERQPCQ
4130
NGATCMPAGE
4140
YEFQCLCRDG
4150
FKGDLCEHEE
4160
NPCQLHEPCL
4170
HGGTCQGTRC
4180
LCPPGFSGPR
4190
CQQGSVHGIA
4200
ESDWHLEGSG
4210
GNDAPGQYGA
4220
YFYDDGFLAL
4230
PGRVFSRSLP
4240
EVPETIELEV
4250
RTSTASGLLL
4260
WQGVEVGESG
4270
RGKDFISLGL
4280
QDGHLVFSYQ
4290
LGSGEARLVS
4300
EDPINDGEWH
4310
RVTALREGRR
4320
GSIQVDGEEL
4330
VSGQSPGPNV
4340
AVNTKGSVYI
4350
GGAPDVAALT
4360
GGRFSSGITG
4370
CIKNLVLHSA
4380
RPGALPPQPL
4390
DLQHRAQAGA
NMRPCPS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005796 | Golgi lumen |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0098609 | cell-cell adhesion |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.