Search Results

Overview

Uniprot IDA0A286ZHV7
Protein NameBasement membrane-specific heparan sulfate proteoglycan core protein
Gene NameHSPG2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1418 KVAAYGGKLRYSLSY
1800 VTFICTAKSKSPAYT
1802 FICTAKSKSPAYTLV
365 DEADCPVKRPEDVCG
799 GPQCNKCKAGFFGDA

Function

Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6

Protein Sequence

10 MGRRAAGALL 20 LALLLQGRLL 30 AVSHGLRAYD 40 GLSLPEDAET 50 ISAGRAGWSY 60 SDLSDDEDFL 70 ADEASGDGVG 80 SGDLGSGDFQ 90 MVYFRALVNF 100 THSIDYSPQL 110 EDAGSEAFRE 120 VSEAVVDTLE 130 SEYLKIPGDQ 140 VVSVVFIKEL 150 DSWVFVELDV 160 GSEGNADGAQ 170 IQEVLHAVIS 180 SGSIASYVTS 190 PQGFQFRRLG 200 TVPQFSRVCT 210 EAEFACHRYN 220 ECVALEYRCD 230 RRPDCRDMSD 240 ELDCEEPVPV 250 LSSLPPTLAE 260 TPPLPPSPPE 270 PEAATARQLP 280 ATPAPQALFP 290 SPDKAAPCGP 300 HEATCRSGHC 310 IPKDYVCDGQ 320 EDCRDGSDEL 330 DCGPAPPCEP 340 NEFPCGNGHC 350 ALKLWRCDGD 360 FDCEDRTDEA 370 DCPVKRPEDV 380 CGPTQFRCVS 390 TNTCIPASFH 400 CDEESDCPDR 410 SDEFGCMPPQ 420 VVTPPQESIQ 430 ASRGQTVTFT 440 CVAIGVPTPI 450 INWRLNWGHI 460 PSHPRVTVTS 470 EGGRGTLIIR 480 DVKEADQGAY 490 TCEAMNARGM 500 VFGIPDGVLE 510 LIPQRGPCPD 520 GHFYLEQSAS 530 CLPCFCFGVT 540 NVCQSSRRFR 550 DKIRLRFDQP 560 NDFKGVNVTM 570 PSQPGMPPLS 580 STQLQIDAAL 590 QEFQLVDLSR 600 RFLVHDSFWA 610 LPEQFLGNKV 620 DSYGGFLHYK 630 VRYELARGTL 640 EPVQRPDVVL 650 VGAGHRLLSR 660 GHTPTQPGTL 670 NQRQVQFSEE 680 HWVHESGRPV 690 QRAEMLQVLQ 700 SLEAVLIQTV 710 YNAKMASVGL 720 SDISMDTTVT 730 YATSHGRAHS 740 VEECRCPIGY 750 SGLSCESCDA 760 HFTRVPGGPY 770 LGTCSGCSCN 780 GHASSCDPVY 790 GHCLNCQHNT 800 EGPQCNKCKA 810 GFFGDATKGT 820 ATACRPCPCP 830 YIDASRRFSD 840 TCFLDTDGQA 850 TCDACAPGYT 860 GRRCESCAPG 870 YEGNPIQPGG 880 KCRPTNQQIV 890 RCDERGSTGT 900 SGEACRCKNN 910 VVGRLCNECV 920 AGSFHLSARN 930 PDGCLKCFCM 940 GVSRQCTSSS 950 WSRAQVLGAS 960 EEPAQFSLTN 970 AAGTHTTSEG 980 ISSPTPGELA 990 FSSFHSLLSG 1000 PYFWSLPSRF 1010 LGDKVTSYGG 1020 ELRFTVTQRP 1030 QPGSVPLHGQ 1040 PLVVLQGNNI 1050 ILEHHTSQEP 1060 SPGQPSTFTV 1070 PFREQAWQRP 1080 DGQPATREHL 1090 LMALAGIDTL 1100 LIQASYTQRP 1110 AESRVSGISM 1120 DVAVPEDTGQ 1130 DPALEVEQCT 1140 CPPGYRGPSC 1150 QDCDTGYTRM 1160 PSGLYLGTCE 1170 RCSCHGHTEV 1180 CEPETGACQG 1190 CQHHTEGPRC 1200 EQCQPGYYGD 1210 AQRGTPQDCQ 1220 PCPCHGAPAA 1230 GQATHTCFLD 1240 TDGHPTCDAC 1250 SPGHSGRHCE 1260 RCAPGYHGNP 1270 SQGQPCRRDD 1280 GQVPEPISCS 1290 CDPQGSISNQ 1300 CDAAGQCQCK 1310 AQVEGLTCSH 1320 CRPHHFYLSA 1330 SNPDGCLPCF 1340 CMGVTQQCSS 1350 SSYTRHLIST 1360 RFAPGDFQGF 1370 ALVNPQRNSR 1380 LTGGFTVEPV 1390 PEGAQLSFGN 1400 FANLGHESFY 1410 WQLPETYQGD 1420 KVAAYGGKLR 1430 YSLSYTAGAQ 1440 GSPLSDPDVQ 1450 ITGNNIMLVA 1460 SQPALQGPER 1470 RSYEIIFREE 1480 FWRRPDGQPA 1490 TREHLLMALA 1500 DLDELLVRAT 1510 FSSMPLAASI 1520 SAVSLEVAQP 1530 GPSEGPRAPE 1540 VEECRCPPGY 1550 VGSSCQDCAP 1560 GYTRTGSGLY 1570 LGHCELCECN 1580 GHSDLCHPET 1590 GACSQCQHNA 1600 AGEFCELCAP 1610 GYYGDATAGT 1620 PEDCQPCACP 1630 LTNPENMFSR 1640 TCESLGAGGY 1650 RCTACEPGYT 1660 GQYCEQCAPG 1670 YVGNPNVRGG 1680 RCLPQADQAP 1690 LVVQVQPPRS 1700 VVPQGGPHSL 1710 RCQVSGSPPH 1720 YFYWSREDGR 1730 PLPSSTQQRH 1740 QGSELHFPSV 1750 QPSDAGVYIC 1760 TCRNLHHANT 1770 SRAELLVTEA 1780 PSKPITVTVE 1790 EQRSQSVRPG 1800 TDVTFICTAK 1810 SKSPAYTLVW 1820 TRLHNGKLPT 1830 RAMDFNGILT 1840 IRNVQPSDAG 1850 TYVCTGSNMF 1860 AMDQGTATLH 1870 VQASGTPSAP 1880 MASIHPPQLT 1890 VQPGQLAEFR 1900 CSATGNPTPT 1910 LEWTGGPGGQ 1920 LPQKAQILGG 1930 ILRLPAVEPS 1940 DQAQYLCHAH 1950 SSAGQHVARA 1960 VLHVHGGNGP 1970 RVQVSPERTQ 1980 VHEGRTVRLY 1990 CRAAGVPSAT 2000 ITWRKEGGSL 2010 PPQARSERTD 2020 IATLLIPAIT 2030 TADAGFYLCV 2040 ATSPAGTAQA 2050 RIQVVVLPAS 2060 GASSPPPVRI 2070 ESSSPSVTEG 2080 QTLDLNCVVT 2090 GLAYTQVTWY 2100 KRGGSLPPHA 2110 QVHGPRLRLS 2120 HVSPADSGEY 2130 VCRVENESGP 2140 KEASIIVSVL 2150 HSTHSAYTPA 2160 PGSTHPIRIE 2170 SSSSHVAEGQ 2180 TLDLNCVVPG 2190 QAHAQVTWHR 2200 RGGSLPARHQ 2210 THGSRLRLHQ 2220 VSPADSGEYV 2230 CRVVLGSGPL 2240 ESSVLVTIEA 2250 SDSGTGSIPR 2260 PIPPVRIESS 2270 SPTVAEGQTL 2280 DLNCVVAGQA 2290 HAQVTWYKRG 2300 GSLPARHQVR 2310 GSRLYIFQAS 2320 PADAGEYVCR 2330 ASNGVEATIT 2340 VTVTRTQGAN 2350 FAYPPGSTPI 2360 RIEPSSSHVA 2370 EGQTLDLNCV 2380 VPGQAHAQVT 2390 WHKRGGSLPA 2400 RHQTHGSLLR 2410 LYQVSPADSG 2420 EYVCRIVGGS 2430 VPLEASVLVT 2440 IEPADSVPAL 2450 GVTPPVRIES 2460 SSSHVAEGQT 2470 LDLNCLVSGQ 2480 AHAQVTWHKR 2490 GGSLPARHQV 2500 HGSRLRLPQV 2510 TPADSGEYVC 2520 RVVSSSGTQE 2530 ASVLVTIQQR 2540 LGPSRPQSVV 2550 YPVRIESSSD 2560 SLANGHTLDL 2570 NCLVASQAPH 2580 TITWYKRGGS 2590 LPSRHQIVGS 2600 RLRIPQVTPA 2610 DSGEYVCHVS 2620 NGAGSQETSL 2630 IVTIQGGGSS 2640 HVPSVSPPIR 2650 IESSSPTVVE 2660 GQTLDLTCVV 2670 AGQPQATITW 2680 YKRGGSLPAR 2690 HQAHGSHLRL 2700 HQMSVADSGE 2710 YVCRANNNID 2720 AQEASIVVSV 2730 SPSTRSPAVP 2740 GGAMPIRIES 2750 SSSHVAEGQT 2760 LDLNCVVPGQ 2770 AHAQVTWHKR 2780 GGSLPTHHQA 2790 HGSRLRLYQL 2800 SPADSGEYVC 2810 RVVSSSGPLE 2820 ASVLVTIEAS 2830 GSGTVLVPAA 2840 GGTPPIRIET 2850 SSSHVAEGQT 2860 LDLKCVVPGQ 2870 AHAQVTWHRR 2880 GGSLPARHQV 2890 HGPLLRLNQV 2900 SPADSGEYSC 2910 RVTGSSGTQE 2920 ASVLVTIEAS 2930 SPSPIPAPGL 2940 AQPIYIEASS 2950 SHVTEGQTLD 2960 LNCVVPGQAH 2970 AQVTWHKHGG 2980 SLPARHQTHG 2990 SRLRLHQVSQ 3000 ADSGEYVCRV 3010 VGISGPELEA 3020 SFTVTVPPSA 3030 GSSYRLRSPV 3040 ISIDPPSSTV 3050 QQGQDASFKC 3060 LIHDGAAPIS 3070 LEWKTRNQEL 3080 EDNVHISPNG 3090 SIITIVGTRP 3100 SNHGAYRCVA 3110 SNAYGVAQSV 3120 VTLSVHGPPT 3130 VSVLPEGPVR 3140 VKEGKAITLE 3150 CVSAGEPRSS 3160 ARWTRIGAPT 3170 NLEQRLHGLL 3180 DSHTLLQISS 3190 AKPSDAGIYV 3200 CLAQNALGTA 3210 QKRVEVIVDT 3220 GIMAPGAPQV 3230 QVEEAELTVE 3240 AGHTATLRCS 3250 ATGSPTPTIH 3260 WSKLRSPLPW 3270 QHQLEGDTLI 3280 IPRVAQQDSG 3290 QYICNATSPA 3300 GHAEATIALH 3310 VESPPYATTV 3320 PEHASVRAGE 3330 TVHLQCLAHG 3340 TPPLTFQWSR 3350 VGGNLPSRVT 3360 ARKEMLLFEP 3370 AAPEDSGRYR 3380 CRVTNKVGSA 3390 EAFAQVLVQG 3400 PSGSLPATPH 3410 PAGATPAVQV 3420 TPQLETKSIG 3430 ASVEFHCIVP 3440 SDQGTQLRWV 3450 KEGGQLPPGH 3460 SVHDGVLRIQ 3470 NLDQSCQGTY 3480 VCQAYGPWGQ 3490 AQASAQLVVQ 3500 ALPSVLINIR 3510 TSVQTVVVGH 3520 SVEFECLALG 3530 DPKPQVTWSK 3540 VGGPLRPGIV 3550 QTGGIVRIAH 3560 VELADAGQYR 3570 CTATNAAGTT 3580 QSHVLLLVQA 3590 LPQISTPPEV 3600 RVPAGSAAVF 3610 PCMASGYPTP 3620 DISWSKLDGN 3630 LPPDSRLENN 3640 MLLLPSVRPQ 3650 DAGTYVCTAT 3660 NRQGKVKAFA 3670 HLQVPERVVP 3680 YFTQTPHSFL 3690 PLPTIKDAYR 3700 KFEIKITFRP 3710 DSADGMLLYN 3720 GQKRIPGSPT 3730 NLANRQPDFI 3740 SFGLVGGRPE 3750 FRFDAGSGMA 3760 TIRHPTPLAL 3770 GQFHTVTLLR 3780 SLTQGSLIVG 3790 SLTPVNGTSQ 3800 GKFQGLDLNE 3810 ELYLGGYPDY 3820 GAIPKAGLSS 3830 GFVGCVRELR 3840 IQGEEIVFHD 3850 LNLTAHGISH 3860 CPTCRDRPCQ 3870 NGGHCQDSES 3880 SSYVCMCPAG 3890 FTGSRCEHSQ 3900 ALHCHPEACG 3910 PDATCVNRPD 3920 GRGYTCRCHL 3930 GRSGRRCEEG 3940 VTVTTPSMSG 3950 TGSYLALPAL 3960 TNTHHELRLD 3970 VEFKPLAPDG 3980 ILVFSGGQSG 3990 PVEDFVSLAM 4000 VGGHLEFRYE 4010 LGSGLAILRS 4020 SEPLALGRWH 4030 HVSAERFNKD 4040 GSLRVNGGRP 4050 VLRSSPGKSQ 4060 GLNLHTLLYL 4070 GGVEPSVQLP 4080 PATNVSAHFH 4090 GCIGEVSVNG 4100 KRLDLTYSFL 4110 GSRGIGQCYD 4120 SSPCERQPCQ 4130 NGATCMPAGE 4140 YEFQCLCRDG 4150 FKGDLCEHEE 4160 NPCQLHEPCL 4170 HGGTCQGTRC 4180 LCPPGFSGPR 4190 CQQGSVHGIA 4200 ESDWHLEGSG 4210 GNDAPGQYGA 4220 YFYDDGFLAL 4230 PGRVFSRSLP 4240 EVPETIELEV 4250 RTSTASGLLL 4260 WQGVEVGESG 4270 RGKDFISLGL 4280 QDGHLVFSYQ 4290 LGSGEARLVS 4300 EDPINDGEWH 4310 RVTALREGRR 4320 GSIQVDGEEL 4330 VSGQSPGPNV 4340 AVNTKGSVYI 4350 GGAPDVAALT 4360 GGRFSSGITG 4370 CIKNLVLHSA 4380 RPGALPPQPL 4390 DLQHRAQAGA NMRPCPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005796 Golgi lumen
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0050839 cell adhesion molecule binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007420 brain development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0098609 cell-cell adhesion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.