Overview
| Uniprot ID | A0A286ZI92 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 294 |
TSFKNSTKSWVRFSG |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA
Protein Sequence
10
MPPKRIAKRR
20
SPPEDALPKS
30
KKVKVSHRSH
40
STEPGLVLTL
50
GQGDVGQLGL
60
GENVMERKKP
70
ALVPIPEDIV
80
QAEAGGMHTV
90
CLSKSGQVYS
100
FGCNDEGALG
110
RDTSVEGSEM
120
VPGKVELQEK
130
VVQVSAGDSH
140
TAALTEDGRV
150
FLWGSFRDNN
160
GVIGLLEPMK
170
KSMVPVQVQL
180
SMPVVKVASG
190
NDHLVMLTAD
200
GELYTLGSGE
210
QGQLGRVPEL
220
FANRGGRQGL
230
ERLLVPKCVM
240
LKSRGSRGHV
250
RFQDAFCGAY
260
FTFAISSEGH
270
VYGFGLSNYH
280
QLGTPGTESC
290
FVPQNLTSFK
300
NSTKSWVRFS
310
GGQHHTVCMD
320
SEGRAYSLGR
330
AEYGRLGLGE
340
GAEEKSVPTL
350
ISRLPAVSSV
360
ACGASVGYAV
370
TKDDEMSTAD
380
GTEMQRAVLV
390
MTCICPDWQR
LWL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:0051301 |
cell division |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.