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Overview

Uniprot IDA0A286ZIC1
Protein NameGelsolin
Gene NameGSN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
126 GGVASGFKHVVPNEV
142 VQRLFQVKGRRVVRA
194 LKATQVSKGIRDNER
287 CFILDHGKDGKIFVW
290 LDHGKDGKIFVWKGK
295 DGKIFVWKGKQANTE
309 EERKAALKTASDFIS
624 RLFACSNKIGRFVIE
677 TEALTSAKRYIETDP

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Protein Sequence

10 MVVEHPEFLK 20 AGKEPGLQIW 30 RVEKFDLVPV 40 PPNLYGDFFT 50 GDAYVILKTV 60 QLRNGNLQYD 70 LHYWLGNECS 80 QDESGAAAIF 90 TVQLDDYLNG 100 RAVQHREVQG 110 FESATFLGYF 120 KSGLKYKKGG 130 VASGFKHVVP 140 NEVAVQRLFQ 150 VKGRRVVRAT 160 EVPVSWESFN 170 RGDCFILDLG 180 NDIYQWCGSN 190 SNRYERLKAT 200 QVSKGIRDNE 210 RSGRAHVHVS 220 EEDAEPAGML 230 QVLGPKPTLP 240 EGTEDTVKED 250 AANRKLAKLY 260 KVSNGAGTMT 270 VSLVADENPF 280 AQGALKSEDC 290 FILDHGKDGK 300 IFVWKGKQAN 310 TEERKAALKT 320 ASDFISKMNY 330 PKQTQVSVLP 340 EGGETPLFKQ 350 FFKNWRDPDQ 360 VDGPGLSYLS 370 SHIANVERVP 380 FDAATLHTST 390 AMAAQHGMDD 400 DGTGQKQIWR 410 IEGSNKVPVD 420 PATYGQFYGG 430 DSYIILYNYR 440 HGGRQGQIIY 450 NWQGAQSTQD 460 EVAASAILTA 470 QLDEELGGTP 480 VQSRVVQGKE 490 PAHLMSLFGG 500 KPMIIYRGGT 510 SREGGQTAPA 520 STRLFQVRAS 530 SSGATRAVEV 540 IPKAGALNSN 550 DAFVLKTPSA 560 AYLWVGTGAS 570 EAEKTGAQEL 580 LRVLRAQPVQ 590 VAEGSEPDSF 600 WEALGGKAAY 610 RTSPRLKDKK 620 MDAHPPRLFA 630 CSNKIGRFVI 640 EEVPGELMQE 650 DLATDDVMLL 660 DTWDQVFVWV 670 GKDSQEEEKT 680 EALTSAKRYI 690 ETDPANRDRR 700 TPINVVKQGF 710 EPPSFVGWFL 720 SWDDNYWSVD 730 PLDRAIAELA A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0060271 cilium assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.