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Overview

Uniprot IDA0A286ZIE8
Protein NameADP/ATP translocase
Gene NameSLC25A4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
147 RLAADVGKGAAQREF
166 NCLAKIFKSDGLRGL
263 DCWRKIAKDEGPKAF
43 LQVQHASKQISAEKQ
96 FAFKDKYKQIFLGGV

Function

Catalyzes the exchange of ADP and ATP across the membrane

Protein Sequence

10 MSDQAWSFLK 20 DFLAGGVAAA 30 ISKTAVAPIE 40 RVKLLLQVQH 50 ASKQISAEKQ 60 YKGIIDCVVR 70 IPKEQGFLSF 80 WRGNLANVIR 90 YFPTQALNFA 100 FKDKYKQIFL 110 GGVDRHKQFW 120 RYFAGNLASG 130 GAAGATSLCF 140 VYPLDFARTR 150 LAADVGKGAA 160 QREFTGLGNC 170 LAKIFKSDGL 180 RGLYQGFNVS 190 VQGIIIYRAA 200 YFGVYDTAKG 210 MLPDPKNVHI 220 IVSWMIAQTV 230 TAVAGLVSYP 240 FDTVRRRMMM 250 QSGRKGADIM 260 YTGTVDCWRK 270 IAKDEGPKAF 280 FKGAWSNVLR 290 GMGGAFVLVL YDEIKKYV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005757 mitochondrial permeability transition pore complex
Molecular Function GO:0005471 ATP:ADP antiporter activity
Molecular Function GO:0017077 oxidative phosphorylation uncoupler activity
Molecular Function GO:0015078 proton transmembrane transporter activity
Biological Process GO:1990845 adaptive thermogenesis
Biological Process GO:0140021 mitochondrial ADP transmembrane transport
Biological Process GO:1990544 mitochondrial ATP transmembrane transport
Biological Process GO:0060546 negative regulation of necroptotic process
Biological Process GO:1901526 positive regulation of mitophagy
Biological Process GO:0046902 regulation of mitochondrial membrane permeability

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.