Search Results

Overview

Uniprot IDA0A286ZIJ1
Protein NameXaa-Pro aminopeptidase 1
Gene NameXPNPEP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
196 VKENLVDKIWTDRPE
330 ASLSPREKVWVSDKA
347 AVSEAIPKDHRCCMP
593 VVLVVPVKTKYNFNN
645 TCRDVIGKELQKQGR
668 RETQPISKQH*****

Function

Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin

Protein Sequence

10 MAASRKAPRV 20 RANYQDFQLK 30 NLRIIEPNEV 40 TRSGYPGVGT 50 DGRMAPKVTS 60 ELLRQLRQAM 70 KNLEYVTEPI 80 QAYIIPSGDA 90 HQSEYIAPCD 100 CRRAFVSGFD 110 GSAGTAIITE 120 EHAAMWTDGR 130 YFLQAAKQMD 140 SNWTLMKMGL 150 KDTPTQEDWL 160 VSVLPEGSRV 170 GVDPLIIPTD 180 YWKKMAKVLR 190 SAGHHLVPVK 200 ENLVDKIWTD 210 RPERPCKPLL 220 TLGLDYTGIS 230 WKDKVADLRL 240 KMAERNVVWF 250 VVTALDEIAW 260 LFNLRGSDVE 270 HNPVFFSYAI 280 IGLETIMLFI 290 DGDRIDTPSV 300 KEHLLFDLGL 310 EAEYRIQVLP 320 YKSILSELKV 330 LCASLSPREK 340 VWVSDKASYA 350 VSEAIPKDHR 360 CCMPYTPICI 370 AKAVKNSAES 380 EGMRRAHIKD 390 AVALCELFNW 400 LEKEVPKGGV 410 TEISAADKAE 420 EFRRQQADFV 430 DLSFPTISST 440 GPNGAIIHYG 450 SNFSTSSPVY 460 LSKSLFRVKI 470 NLSFLLERDG 480 TTDVTRTMHF 490 GTPTAYEKEC 500 FTYVLKGHIA 510 VSAAVFPTGT 520 KGHLLDSFAR 530 SALWDSGLDY 540 LHGTGHGVGS 550 FLNVHEGPCG 560 ISYKTFSDEP 570 LEAGMIVTDE 580 PGYYEDGAFG 590 IRIENVVLVV 600 PVKTKYNFNN 610 RGSLTFEPLT 620 LVPIQTKMID 630 VDSLTDKECD 640 WLNNYHLTCR 650 DVIGKELQKQ 660 GRQEALEWLI 670 RETQPISKQH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0030145 manganese ion binding
Molecular Function GO:0070006 metalloaminopeptidase activity
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0010815 bradykinin catabolic process
Biological Process GO:0043069 negative regulation of programmed cell death
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.