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Overview

Uniprot ID	A0A286ZIJ9
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	PFKM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
708	FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MHKEEVHLKF 20 FMCVIQSRQL 30 VRTPQRTEWI 40 MTHEEHHAAK 50 SLGVGKAIAV 60 LTSGGDAQGM 70 NAAVRAVVRV 80 GIYTGARVFF 90 VHEGYQGLVD 100 GGDNIREATW 110 ESVSMMLQLG 120 GTVIGSARCK 130 DFREREGRLR 140 AAHNLVKRGI 150 TNLCVIGGDG 160 SLTGADTFRS 170 EWGDLLNDLQ 180 KAGKITAEEA 190 NKSSYLNIVG 200 LVGSIDNDFC 210 GTDMTIGTDS 220 ALHRIIEIVD 230 AITTTAQSHQ 240 RTFVLEVMGR 250 HCGYLALVTS 260 LSCGADWVFI 270 PECPPDDAWE 280 EHLCRRLSET 290 RTRGSRLNII 300 IVAEGAIDKN 310 GQPITSENIK 320 DLVVKRLGYD 330 TRVTVLGHVQ 340 RGGTPSAFDR 350 ILGSRMGVEA 360 VMALLEGTPD 370 TPACVVSLSG 380 NQAVRLPLME 390 CVQVTKDVTK 400 AMNEKRFDEA 410 MKLRGRSFMN 420 NWEVYKLLAH 430 VRPPVTKSGS 440 YTVAVMNVGA 450 PAAGMNAAVR 460 STVRIGLIQG 470 NRVLVVHDGF 480 EGLAKGQIEE 490 AGWSYVGGWT 500 GQGGSKLGTK 510 RTLPKKSFEQ 520 ISANITKFNI 530 QGLVIIGGFE 540 AYTGGLELME 550 GRKQYDELCI 560 PFVVIPATVS 570 NNVPGSDFSV 580 GADTALNTIC 590 MTCDRIKQSA 600 AGTKRRVFII 610 ETMGGYCGYL 620 ATMAGLAAGA 630 DAAYIFEEPF 640 TIRDLQVNVE 650 HLVQKMKTTV 660 KRGLVLRNEK 670 CNENYTTDFI 680 FNLYSEEGKG 690 IFDSRKNVLG 700 HMQQGGSPTP 710 FDRNFATKMG 720 AKAMNWMSGK 730 IKESYRNGRI 740 FANTPDSGCV 750 LGMRKRALVF 760 QPVTELKEQT 770 DFEHRIPKEQ 780 WWLKLRPILK 790 ILAKYEIDLD 800 TSEHAHLEHI 810 TRKRSGEATI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.